18 weeks of chemotherapy-treatment results in reduced muscle mass and muscle fiber cross-sectional area, reduced oxidative capacity, reduced muscle strength and increased muscle fat mass.
ID
Bron
Aandoening
Cancer cachexia
Spierverlies bij kanker
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Changes in muscle mass, measured with dexa scan and fiber cross sectional area in muscle biopsy from the vastus lateralis muscle.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
18 weeks of chemotherapy-treatment results in reduced muscle mass and muscle fiber cross-sectional area, reduced oxidative capacity, reduced muscle strength and increased muscle fat mass.
Onderzoeksopzet
All interventions will take place 2 weeks before the start of chemotherapy and after 18 weeks of chemotherapy.
Onderzoeksproduct en/of interventie
All interventions will be performed before and after 18 weeks of chemotherapy:
1. Maximal strength assesment;
2. Maximal cycling test;
3. Muscle biopsy from the vastus lateralis muscle;
4. Venous blood sample;
5. Dexa scan;
6. Questionnaires regarding physical activity, dietary status and quality of life.
Publiek
De Run 4600
M. Beelen
Veldhoven 5500 MB
The Netherlands
+31 (0)40 8888688
m.beelen@mmc.nl
Wetenschappelijk
De Run 4600
M. Beelen
Veldhoven 5500 MB
The Netherlands
+31 (0)40 8888688
m.beelen@mmc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Female breast cancer patients;
2. Age between 30-65 years;
3. 18 weeks of chemotherapy treatment with TAC.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Participation in an exercise rehabilitation program during the study;
2. Chronic diseases that influence skeletal muscle characteristics, like type II diabetes mellitus, chronic obstructive pulmonary disease, chronic heart failure;
3. Chronic inflammatory disorders, like rheumatoid arthritis, colitis ulcerosa or Crohn's disease;
4. Musculoskeletal disorders that cause an inability to perform exercise.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL3281 |
| NTR-old | NTR3449 |
| CCMO | NL40186.015.12 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON37832 |