10663 resultaten
In follow up measurements compared to pre-treatment measurement 1) WITHIN the treatment group there is a decline in the severity of PTSD symptoms and percentage of PTSD diagnoses; 2) BETWEEN treatment group and care-as-usual group there is more…
The purpose of this study is: 1. To identify clinical and biological predictors for the development of IRIS in HIV infected patients and; 2. To obtain insight into the pathogenesis of this syndrome; 3. To describe the epidemiological pattern of IRIS…
1a. Changes in outcome measures of anxiety can be partly explained by changes in self-reported thougths; 1b. Changes in outcome measures of anxiety can be partly explained by changes in selective attention and by changes in fear relevant cognitive…
1, the effect of SLT diminishes in time; how fast does IOP get below target IOP after SLT? 2, is a repeat SLT effective to get/keep IOP under target IOP? 3, is there a racial difference in effect of SLT?
The present study will assess the composition of the oral microbiome in patients who have been referred to the NKCV (Nederlands Kenniscentrum Chronische Vermoeidheid) for treatment for complaints of severe and protracted fatigue. Objective…
Assessment of feasibility of neoadjuvant chemotherapy consisting of docetaxel, cisplatin and capecitabine in resectable localized gastric cancer (stage Ib-IVa) and the introduction of the D1extra-lymphadenectomy as the standardized surgical…
An increase in subjective memory performance will result in increased quality of life and social participation.
The main objective of the present study is to evaluate (cost)effectiveness of Dementia Care Mapping (DCM)intervention in nursing home dementia care by performing a large RCT study.
We hypothesize that the Ketogenic diet will be cost-effective compared to usual care.
To compare a ventilation strategy that uses conservative targets (PaO2 55-80 mmHg (7.3-10.7 kPa)) with one that uses conventional oxygenation targets (PaO2 110-150 mmHg (14.7-20 kPa)) for arterial oxygenation. Primary endpoint is all-cause mortality…
The Trammpolin® medial meniscus prosthesis is intended to restore the function of the natural meniscus to provide unicompartmental pain relief in the meniscus-deficient knee and redistributes the loads transmitted across the knee joint. The ability…
Microarray: 1. To identify a tumour genetic profile that is associated with early metastatic spread in patients presenting with oesophageal cancer and no evidence of distant metastasis at the time of diagnosis; 2. To distinguish oesophageal cancer…
We hypothesize that the vascularity of the fibroid is associated with: 1. Growth potential of the fibroid; 2. The fibroid size reduction after GnRHa treatment.
Many patients, especially patients with a chronic illness, experience difficulties in following treatment recommendations. Adherence to long-term therapy for chronic illnesses in developed countries averages only 50%. As a result of poor adherence,…
The aim of the present study is: can a single case observation of two distinct phases during systole (laminar and turbulent) be confirmed in other patients with aorta stenosis?
Differences in the healthcare, workplace, legislative, and personal systems (see figure) as well as evaluator and patient characteristics may better explain differences in FCE results
LRRK2 activity is linked to central mechanisms of Parkinson’s disease pathology through its role in lysosomal function, and LRRK2 kinase inhibitors, such as DNL201 (IND Number: 133665) represent a new class of therapeutics with potential to address…
The one-year graft survival of a second kidney transplant will be inferior to the one-year graft survival of a first kidney transplant.
The primary aim of the study is: 1. To assess the role of an early intensification of two "AML" induction blocks versus protocol Ib directly after induction, in a randomized way in MR and HR patients. Secondary aims are: 2. To assess the…
To compare the clinical and cost-effectiveness of pelvic floor muscle training versus TVT/TVT-O surgery as primary treatment of moderate to severe female urinary incontinence.