190 resultaten
Half dose Urokinase (50.000IE/h) will significantly reduce hemorrhagic complications compared with the standard dose Urokinase (100.000IE/h) with comparable technical success rate
Multi-centre open label clinical trial.
Simvastatin (an HMG-CoA reductase inhibitor) induces apoptosis in vitro and sensitizes the myeloma cell to chemotherapy. This is the first clinical trial to test if in vivo there is the same sensitization in relapse or refractory multiple myeloma.
Intrathecal methylprednisolone reduce the features of central sensitization in patients with complex regional pain syndrome type 1 having symptoms longer than 6 months and shorter than 6 years.
Chronic sleep disorders are associated with dysfunctioning during the day. Circadian rhythm disorders are a frequently occurring cause of chronic sleep disorders. The time at which the endogenous melatonin production starts to rise plays a key-role…
Pain Rehabilitation Programs (PRP’s) are proven effective for patients with chronic musculoskeletal pain (CMP). Evidence about the relationship of dose on the effect of PRP however, is unavailable. We hypothesized that shortening PRP will not be…
Vernakalant is superior to Amiodarone and rate control alone in the acute conversion of recent onset atrial fibrillation (AF) in critically ill patients admitted to the medical ICU.
Part 1 Single Ascending Dose (SAD) - To evaluate the safety and tolerability of a single oral dose of prodrug, ABX-002, in healthy adult subjects Part 2 Multiple Ascending Dose (MAD) -To evaluate the safety and tolerability of once daily oral…
To develop a dosing nomogram of irinotecan in patients homozygous polymorphic for UGT1A1*28 and/or UGT1A1*93 in order to reduce the incidence of severe irinotecan-associated toxicity, defined as febrile neutropenia in the first 2 cycles (amendment…
The gastric balloons are expected to remain in the stomach for approximately four weeks, after which they burst and are fecally excreted. It is further hypothesised that intragastric balloons can provide a surrogate stomach fill, inducing an…
The RAINBOW study: Rheumatoid Arthritis ImplemeNtation of Biological dose Optimization in real World
We hypothesize that a multifaceted implementation strategy can stimulate the use of tight control and bDMARD dose optimization in clinical practice, measured by decreased bDMARD use and non-inferiority on disease activity at 18 months.
90-day treatment with a selected probiotics mixture can reconstitute the microbiome diversity after antibiotic treatment for community-acquired pneumonia.
Femtosecond (FS) laser aided keratoplasty for KC is superior to MALK.
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Perioperative esmolol infusion titrated for heart rate control as an add-on to standard therapy including a long acting oral beta-blocker will improve heart rate control and decrease perioperative myocardial ischemia, without an increase in…
A family involvement program will reduce the number of unplanned readmissions in adult patients undergoing major abdominal surgery.
Secondary cytoreductive surgery added to chemotherapy will increase progression free survival in selected patients with first platinum sensitive recurrence of ovarian cancer with a minimal negative effect on their health-related quality of life.
It is hypothesized that a preoperative oral antibiotic prophylaxis, that is administered in addition to perioperative intravenous prophylaxis, will lead to a reduction in postoperative would infections after colorectal surgery
Acutely hospitalized older patients frequently suffer from inadequate sleep. Insufficient sleep can lead to patient distress and delayed recovery from acute illness or a surgical procedure. Currently, no evidence-based treatments exist for sleeping…
Sensory properties of diary products predict expected satiation when test products are iso-caloric. Expected satiation will change after repeated consumption of the products when properties are not congruent with caloric content.