584 resultaten
PVAT plays an important role in driving vascular ageing manifested by medial smooth muscle cell (SMC) dedifferentiation into an osteogenic phenotype that induces intimal and/or medial calcification. I furthermore hypothesize that this process of…
This evaluation does not have a hypothesis to be tested since it is intended to evaluate the workflow and usability of the new software solution, without prior defined performance criteria.
Aim of the MANCO study is to establish for once and for all that monitoring the effect of heparin during NCVI is essential to ensure the individual patient of safe and tailor-made anticoagulation. Not measuring the effect of the administered heparin…
It is hopthesized that a multidimensional implementation approach with multiple interventions integrated in the usual care will improve physical behaviour during hospitalization
Addition of threedimensional breast ultrasound to the conventional diagnostic workup improves diagnostic accuracy in women referred from breast cancer screening with a BI-RADS 0 test result.
Neutralizing antibody titers after fractional dosing of yellow fever vaccine are comparable to standard dose vaccination, ten years after primary vaccination
IPA as first-line therapy in the Emergency Department leads to: - faster initiation of symptomatic treatment for nauseous patients - more patients receiving symptomatic treatment for nausea - a decrease in the use of conventional anti-emetics - a…
Is there a significant difference in Anterior/Posterior stability between MRK, LCS and NexGen total knee prosthesis 1 year post-op?
- Aim 1: regular physical activity reduces the risk of cardiovascular events and is associated with better survival. Earlier studies show that exercise might also have a direct positive effect on myocardial tissue, probably due to ischaemic…
This pilot study aims to report on the diagnostic value of indocyanine green and fluorescence laparoscopy on vascularization defects of the stomach and spleen during antireflux surgery. It is our hypothesis that many splenic and gastric infarctions…
Proactive and reactive trough level measurements of TNFalpha blockers are useful in standard care by aiding an individualized treatment strategy, preventing loss of efficacy and reducing disease flares, while being more cost-effective than symptom-…
The objective of the study is to determine whether optical measurements can support pulse detection during cardiopulmonary resuscitation. The optical measurements will be compared with standard measurements such as palpation,…
We hypothesise that the braced condition is significantly more similar to the affected side than the non-braced condition
The primary objective is to elucidate which circuits of the social decision making network are involved in IED and to what extent. Candidate mechanisms are the mesolimbic reward circuit and the social emotional cortical-amygdala connections. Our…
Docetaxel has a narrow therapeutic index and shows a wide interpatient variability in clearance and toxicity. There is a need for a tool to predict efficacy of docetaxel in individual patients. We hypothesize that the pharmacokinetics of a microdose…
The primary objective of this study is to develop an objective, clinical relevant classification model of disease severity for patients with HF based on an extensive, complete dataset of patients with HF.
There are three main hypotheses: 1.visceral adiposity is associated with increased risk of recurrence and with decreased survival, 2.indicators of low muscle quality (low muscle mass, low muscle attenuation and increased inter-muscular fat areas)…
The main objective of this study is to develop a method to measure the severity of bronchial bleeding during bronchoscopy. We hypothesize that measurement of bronchial bleeding during bronchoscopy can be performed with different techniques, among…
In this study we aim to investigate whether intestinal acetate production by gutmicrobiota is related to (postprandial) plasma acetate levels, insulin secretion/sensitivity and the CNS regulation of food intake (fMRI).