1307 resultaten
The hypothesis of this study is that integral AF management in primary care - including case-management for anticoagulation (stroke prevention) as well as appropriate attention given to all cardiac and non-cardiac comorbidities - is at least non-…
We hypothesize that it is possible to culture circulating tumor cells obtained by leukapheresis into organoids.
Not applicable
The primary objective is to determine whether JWH-018 can be safely administered in healthy volunteers in doses up to 3 mg. Therefore participants will be continuously monitored by a medical doctor and vital signs, laboratory clinical safety and…
Pelvic floor muscle training supported by vaginal and abdominal biofeedback, serious games and a web-portal is non-inferior to pelvic floor muscle training alone.
Primary: The number and duration of asthma exacerbations will diminish with the regular use of a bacterial lysate. Secondary: -Regular bacterial lysate treatment improves health (pulmonary function, quality of life, medication use). - Respiratory-…
use of metformin and a hypocaloric diet result in reduced thyroid iodide uptake.
Type 2 diabetes is associated with an increased cardiovascular risk. Besides metformin, a new treatment strategy is oral SGLT2 inhibition (dapagliflozon), Although two recently published, first-in-class cardiovascular outcome trials (EmparegMPA-REG…
The current systemic treatment with PD-1 and PD-L1 inhibitors can cause autoimmune side effects. As cervical cancer does not readily metastasize to distant organs but initially to regional lymph nodes we believe that local administration of PD-1/PD-…
Self-management at home in combination with telemedicine in high-risk pregnancies is non-inferior compared to hospital admission regarding safety, cost-effectiveness and patient satisfaction.
The aim of the study is to investigate whether a positive outcome expectancy considering the effectiveness and working mechanisms of health-related serious gaming alone or in combination with playing health-related serious games can optimize food…
The hypothesis is that small buccal dehiscences after implant placement can be reconstructed with a mixture of a bone substitute and autogenous bone with and without coverage of a membrane. -Our second hypothesis is that implants with a small buccal…
To define the optimum laparoscopic anti-reflux operation, ensuring long-term reflux control with minimal postoperative dysphagia and gas-related symptoms
More specifically, the goals of this research project are in subsequent order: 1. To examine whether adult patients following tonsillectomy in the enhanced outcome expectancy condition will experience less pain (and other outcomes), compared to…
Wound dehiscence is the rupturing or splitting apart of the margins of a clean closed incision, which generally appears in the first week after surgery. The aim of this study is to answer the question whether postoperative treatment with a wound…
Short term dietary restriction will lead to lower concentrations of SN-38 in healthy liver tissue (without reducing the intratumoral concentration) and to less toxicity of irinotecan
De analyse van het aantal patiënten waar een mogelijke behandeling kan plaatsvinden op basis van een waargenomen (kiembaan/somatische) moleculaire afwijking (actionable events) bij patiënten met een recidief/refractaire kinderoncologische tumor…
Because of the increasing incidence of work-related musculoskeletal disorders of the upper extremities, the UEWD questionnaire was developed as a riskassessment that takes less time and less expenses then an observation. The aim of this study is to…