1420 resultaten
In this RCT we investigate the effects of two school-based physical activity interventions (aerobic exercises versus coordinative exercises) in primary school children on executive functions and academic achievement. We hypothesize that both aerobic…
•To assess the safety and tolerability of induction doses of ABP-700 and determine dosing regimens that reliably produce drug induced unconsciousness and the pharmacodynamic conditions necessary for induction of general anesthesia with ABP-700 alone…
The use of atorvastatin in persons at high risk of RA is associated with a reduction in de development of arthritis
At equi-analgesia respiratory depression from oxycodone is manifold greater compared to Tapentadol
Is there a diiference in antidepressant efficacy between ECT and a combination of ECT and nortriptyline? Does combination therapy with ECT and nortriptyline result in a faster antidepressant response compared with ECT monotherapy? Does combination…
This study aims at demonstrating the effectiveness of IMR on the illness management skills and recovery of the patients. The added value for participants on different areas of life is examined. The research can contribute to answering the question…
In follow up measurements compared to pre-treatment measurement 1) WITHIN the treatment group there is a decline in the severity of PTSD symptoms and percentage of PTSD diagnoses; 2) BETWEEN treatment group and care-as-usual group there is more…
1. Gatekeeper training is effective in enhancing relevant skills 2. Gatekeeper training will diminish rates of (attempted) suicides at regional level 3. The intervention is cost-effective relative to routine medical care
Surgical procedures are accompanied by high levels of distress and pain in the adult as well as the pediatric population. Music interventions have shown to reduce this anxiety and pain in adult populations. In this study, we will investigate the…
We hypothesize that SNNS might be of great value in early esophageal cancer, especially in the treatment of high-risk early EAC (T1b-tumors). A treatment algorithm consisting of endoscopic resection of the tumor, followed by SNNS and (adjusted) LN…
In this randomized, single blinded controlled trial, we evaluate the role of ketamine as an analgesic component of procedural sedation. We compare the effects of propofol-ketamine versus propofol-alfentanil and propofol-remifentanil for achieving a…
The purpose of the activity and heart rate monitor is to measure and track movement (acceleration) and heartbeat, and derive a number of health-related parameters, which can serve as basis for behavioral change programs leading to e.g. a healthier,…
H1: the exercise intervention is effective in reducing (work-related) fatigue H2: the exercise intervention is effective in improving (work-related) self-efficacy, sleep quality, work ability, cognitive functioning, and aerobic fitness.
Delegation of clozapine monitoring tasks to a Nurse Practitioner (condition A) is at least as safe as Treatment As Usual: physicians perform monitoring tasks themselves (condition B).
1. We hypothesize that exercise training in breast cancer survivors positively affects patients quality of life, on the short- and longterm. 2. We hypothesize that the cohort multiple Randomised Controlled Trial (cmRCT) is a more suitable design for…
The aim of the study is to investigate the effect of conditioning with exogenous oxytocin on endogenous oxytocin release in healthy participants. We hypothesize that conditioning will lead to altered oxytocin levels.
In line with a previous pilot study we hypothesize that 3MDR will significantly decrease PTSD symptom severity in treatment resistant veterans with chronic PTSD in comparison with treatment as usual.
The RAINBOW study: Rheumatoid Arthritis ImplemeNtation of Biological dose Optimization in real World
We hypothesize that a multifaceted implementation strategy can stimulate the use of tight control and bDMARD dose optimization in clinical practice, measured by decreased bDMARD use and non-inferiority on disease activity at 18 months.