504 resultaten
Chronic heart failure (CHF) is a clinical syndrome resulting from a decreased cardiac output, insufficient to maintain adequate tissue oxygenation. Eventually, inadequate tissue oxygenation will lead to pathological alterations, especially at the…
Does heated oxaliplatin reduce the acute peripheral neuropathy complaints in patient with a colorectal carcinoma.
The primary objective is to quantify the learning process of self infusion and the self infusion procedure.
Intranasal administration of cobalamin can be used as an alternative for the standard intramuscular injection of cobalamin in cobalamin deficient patients.
Interferons (IFNs) are a family of cytokines which have important antiviral and antiproliferative properties. They also play an important role in immunomodulation. Type I IFNs have been implicated in autoimmune diseases, including systemic lupus…
1. Measure DNIC and offset analgesia in neuropathic pain patients; 2. Compare DNIC and offset analgesia in chronic pain patients with DNIC and offset analgesia in healthy volunteers; 3. Assess the effect of oral tapentadol on DNIC and offset…
To determine the epidemiology, diagnosis and prognosis of enterovirus (EV) and parechovirus (HPeV) infection in Dutch children. Hypotheses: 1. EVs are one of the most important viral agents of infection in Dutch children; 2. EVs are the major cause…
The use of the laparoscopic insertion technique will lower the proportion of malfunctioning PD-catheters.
1. Providing children with tailored non-smoking advice will prevent them from becoming a smoker; 2. Children receiving tailored non-smoking advice will have stronger cognitions in favour of non-smoking; 3. Prompting children through e-mail and SMS…
Recent research shows that obesity is associated with changed bowel flora composition with a relative abundance of the two dominant bacterial divisions, the Bacteroidetes and the Firmicutes. Interestingly, this specific bacteria associated condition…
After training one arm with a prosthetic simulator it is expected that the other arm will improve.
1. Volume intervention by a diuretic and moderate sodium diet potentiates the antiproteinuric effects of aliskiren in patients with residual albuminuria during conventional RAAS-blockade; 2. Aliskiren neutralizes the reactive rise in plasma renin…
1. The first hypothesis is that treatment of panic disorders with or without agoraphobia with EMDR as well as with CBT will lead to symptom reduction. This symptom reduction is expected to be larger in the EMDR treatment group than in the CBT…
1. The STERK-intervention will prevent early onset of anxiety and mood disorders in offspring (compared to a minimal information condition); 2. The STERK-intervention is cost-effective; 3. The effectiveness of the STERK-training will be influenced…
1. Certolizumab pegol, a TNF inhibitor, has recently been approved in the Netherlands for the treatment of moderate to severe rheumatoid arthritis. As efficacy in daily clinical practice can differ from the clinical (registration) trials, e.g. due…
Chronic Obstructive Pulmonary Disease (COPD) is a chronic, progressive lung disease. The prevalence and associated costs of COPD are projected to increase the upcoming decades. The treatment of COPD aims to reduce risk factors, prevent disease…
The addition of metronomic cyclophosphamide to standard 2nd line treatment with everolimus will improve progression free survival of patients at 4 months from the reported value of 50% to 70% in patients with mRCC.
Primary outcomes with respect to living donation are: Knowledge, risk perception, subjective norm, communication and intention to engage in a certain behavior (choosing living donation). These concepts will be measured among the patient as well as…
Both modalities of IMT will reduce postoperative pulmonary complications and IC stay.