19 resultaten
The RAINBOW study: Rheumatoid Arthritis ImplemeNtation of Biological dose Optimization in real World
We hypothesize that a multifaceted implementation strategy can stimulate the use of tight control and bDMARD dose optimization in clinical practice, measured by decreased bDMARD use and non-inferiority on disease activity at 18 months.
Chronic allograft nephropathy is the main cause of long-term renal transplant failure. The pathogenesis involves amongst others calcineurin inhibitors. We performed a multicenter randomized trial to study the effects of withdrawal of ciclosporin (…
Administration of a lipid emulsion consisting of long-chain triglycerides (LCT-trial) in non-trained individuals, will induce insulin resistance due to increased DAG accumulation and subsequent activation of the PKC pathway in skeletal muscle.…
The aim of this study is to assess the predictive value of the HowRwe questionnaire in relation to the EUROPEP questionnaire by analyzing scores acquired in Dutch GP practices. We expect that high HowRwe scores are associated with an positive…
The study will investigate the effect of a synbiotic test product compared to a control product on the composition and metabolic activity of the gut microbiota of C-section delivered infants.
A cesarean section performed without a clear indication results in additional morbidity and costs without improvement of outcome. The group of women delivering their first baby in cephalic presentation at term is the largest contributor to the…
The formula will be tolerated by at least 90% of the children with cow's milk allergy with a confidence interval of 95%.
Hypothesis 1: Participants who receive either of two CBM interventions will reduce their gambling more than participants completing the placebo intervention immediately after the re-training (post-intervention assessment) and by the 3-and 6-month…
Does lipid accumulation in skeletal muscle and the heart effect mitochondrial function in relation to insulin resistance?
It is assumed that recurrence of appropriate ICD shocks is 30% in the Amiodarone group and 16% in the Ablation group.
Administration of fluoxetine during late brain development (adolescence), but not in adulthood, will result in abnormal outgrowth of the 5-HT system. This long-lasting disturbance of the 5-HT system may be visualized using MRI techniques and can…
The relative risk of developing macular edema in diabetics after cataract surgery is enhanced.
Acute Rockwood type 3 AC-luxations will have a better function after operative treatment with the artroscopic TightRope technique than patients treated conservative.
Het doel van dit onderzoek is het evalueren van de veiligheid en effectiviteit van een gefaseerde epicardiale en endocardiale ablatieprocedure bij patiënten met persisterend of langdurig persisterend boezemfibrilleren door middel van een…
De studie bestaat uit 2 delen. Deel 1: Evaluatie van het seksueel functioneren van MRK(H) vrouwen, het seksueel zelfbeeld, psychologisch en relationeel functioneren van deze vrouwen en het seksueel functioneren van hun partners en vergelijken met…
Subjectieve en objectieve evaluatie van het therapeutische effect van laag-gedoseerde radiotherapie op de pijn en functiebeperking ten gevolge van milde artrose van de heup
Het doel van deze studie is het onderzoeken of de verschillen in DNA methylatie, die gezien zijn bij zij die blootgesteld zijn tijdens de zwangerschap aan de Nederlandse Hongerwinter,door worden gegeven aan een volgende generatie.
Het doel van de studie is het bestuderen van de functionele hypothalame response op glucose ingestie in obese proefpersonen.