4412 resultaten
Non-inferiority (defined as < 12.5% increase) of pooled buffy coat-derived PR platelet concentrates (PR-plasma-PCs) compared to plasma (plasma-PCs) in terms of clinical efficacy determined by WHO grade ≥ 2 bleeding complications.
In line with results from recent pharmacological studies, it is expected that: 1. Inhibiting the cholinergic system by Inversine (Mecamylamine Hydrochloride) results in an impairment of disengagement, but will not affect bias; 2. Inhibiting the…
The primary objective is to demonstrate the non-inferiority of bevacizumab to ranibizumab in the treatment of patients with subfoveal CNV secondary to AMD as determined by the change in best-corrected visual acuity in the study eye from baseline to…
The aim of the pilot trial is to: 1. evaluate the potential effectiveness and effect size of the e-support program for parents of children with a chronic kidney disease; 2. to identify outcome measures most likely to capture potential patient…
An activity stimulation program improves mobility performance and fitness in children with cerebral palsy.
Laparoscopic gastrectomy will result in a lower post-operative burden by means of shorter post-operative hospital stay
The hypothesis of this study is that dosing everolimus 5mg twice daily(BID) instead of 10 mg once daily (QD) decreases the incidence of side effects, as a result of a lower Cmax while maintaining Cmin and AUC.
The aim of this present diagnostic study is to determine the accuracy by which we can detect residual disease after neoadjuvant chemoradiotherapy.
We hypothesize that PEMF-treatment will be of additional value after the primary arthroscopic treatment of an OD, and the resumption of sports can be both improved and accelerated.
By detection of disease specific deviations in emotion processing in unipolar vs bipolar patients, affective neuropsychological tests and fMRI could be used to discriminate between both affective disorders.
Use of the Online Exercise Coach, an online tailored exercise program, will enhance compliance with a prescribed exercise program.
In the Netherlands, case managers play an essential role in the care chain for people with dementia living in the community. Because the profession has just been started, there is a lack of evidence-based practice to provide treatment for agitation…
The mean 12 months eGFR change between adult HIV-1 patients on TDF containing cART without reported NSAID/MRP4-i exposure will be greater than HIV-1 patients on TDF containing cART in the highest quartile of monthly cumulative DDD NSAID exposure (…
Compression therapy is not necessary after VNUS. Patients receiving no compression therapy after VNUS will have similar outcomes in post-operative pain, oedema, and HRQOL, post-operative complications, time to full recovery.
There are many avoidable deaths in hospitals because the care team is not well attuned. Training in emergency situations is generally followed on an individual basis. In practice, however, hospital patients are treated by a team composed of various…
That clozapine treatment compared to risperidone treatment is associated with a significant reduction in subjective craving and in a lower activity of the different functional craving pathways and their associated brain activity patterns.
Eating rate may be related to overweight. Due to a high eating rate, there may not be sufficient time to develop appropriate feelings of satiety, leading to overconsumption. We hypothesise that when eating rate is high, the ad libitum food intake is…
After epilepsy surgery an improvement of the sleep quality and structure can be expected as result of the disappearance or decrease of the daytime and or nocturnal seizures and the reduction of the amount of medication. After implantation of vagus…
Anxiety disorders and depression are common illnesses that have a negative impact on everyday functioning, cause great suffering, and entail both high care costs and loss of production. Recognition, diagnosis and stepped care allocation of treatment…
To assess whether children with relapsed/refractory AML, who do not achieve remission or relapse after treatment with the Relapsed AML 2001/01 standard reinduction protocol (fludarabine, cytarabine and GCSF with or without DaunoXome�), can be…