432 resultaten
Which treatment strategy is the most effective for patients with acute left-sided malignant colonic obstruction: either colonic stenting followed by elective surgery or emergency surgery.
Several open-label pilot studies have shown a promising effect of intrapyloric botulinum toxin injection on symptoms in severe gastroparesis. However, data from randomized, double-blind, placebo-controlled studies are not yet available. We intend to…
The promotion of safe sports participation proves effective in a physical education setting, resulting in a reduction of lower extremity injuries in children.
To evaluate the response to adalimumab treatment in TNF-alpha blockade naïve patients and patients who failed prior other anti-TNF-alpha treatment and to understand the mechanisms underlying the clinical response to TNF-alpha blockade.
RhDNase can liquefy mucus in children with an atelectasis during mechanical ventilation, resulting in improved mucociliary clearance, less mucus retention and less airways obstruction, thereby enhancing the rate of resolution of an atelectasis.…
Antisense oligoribonucleotides inducing exon skipping is a promising approach to restore dystrophin synthesis in patients with Duchenne.
Goal: 1. Defining normal electophysiologic matarution in premature infants by quantitative analysing techniques; 2. Identifying circumstances that disturb normal electrophysiologic maturation.
Baseline variables such as Harm Avoidance and other personality, biological and electrophysiological measures will predict treatment outocme to an SSRI.
DBS in the nucleus accumbens can lead to long-term improvement of obsessive-compulsive symptoms and funtioning, without unacceptable side-effects.
1. In the first intervention group, the % of subjects who meet the national physical activity guideline will significantly increase; 2. In the second intervention group the % of subjects who meet the national physical activity guideline will…
The intervention lead to: 1. More knowledge about (the use of) prescribed medicines; 2. A better use of medicines during the stay in the hospital and after discharge.
Measurement of airways hyperresponsiveness by mannitol (Aridol©) as compared to methacholine saves time to the lung function technician, while being as sensitive to discern hyperresponsive from normo-responsive, and being at least equally acceptable…
Based on systematic reviews concerning effective treatments in children with migraine a medical treatment (propanolol) as well as a non-medical treatment (relaxation therapy) appear to be effective compared to no treatment or placebo. however their…
Aetiology of late-onset depressive spectrum disorders may be different from the aetiology of early-onset depression. Concordant with the supposed aetiology of dementia, it has been postulated that chronic low grade immune activation plays a role in…
Our hypothesis is that rebound thrombin generation occurs in ICU-patients after abrupt cessation of heparin treatment in terms of elevation of coagulation-markers and reduction fibrinolysis-markers; IV-weaning of heparin reduces this rebound…
Low dose nadroparin will prevent symptomatic and asymptomatic catheter-related deep vein thrombosis in patienten treated with high dose chemotherapy.
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Information-processing: 1. Changes in measures of severity of OCD are explained (partially) by changes in measures of meta-cognitions (explicit and/or implicit); 2. Changes in measures of meta-cognitions (explicit and implicit) precede changes in…
Mechanical bowel preparation (MBP) is common practice in elective colorectal surgery. In recent literature the value of MBP is subject of discussion. This non-inferiority, randomized study evaluates the value of MBP before colorectal surgery.
To compare the efficacy of maintenance therapy with an equal monthly dose of imiglucerase when administered at a frequency of once every four weeks versus once every one or two weeks, in adult type I Gaucher disease patients in stable and good…