512 resultaten
Statin-treatment has been shown to normalize the learning- and attention deficits in NF1 +/- mice by decreasing Ras activity. The fact that statins are effective in NF1 mice, combined with their very good safety profile, makes them an ideal…
Acclydine is a plant sourced alkaloid which has effects on protein structure and metabolism. In particular it leads to the activation of the pituitary to increase release of growth hormone. The GH axis has been shown to be disturbed in CFS, so this…
Test in a phase III randomised study whether an improvement of loco-regional control can be obtained with accelerated postoperative radiotherapy (66 Gy in 5 weeks) as compared to conventionally fractionated radiotherapy (66 Gy in 7 weeks) in…
Long-term administration of Ibopamine hydrochloride eye drops restores and maintains intraocular pressure in patients with hypotony following vitreoretinal surgery for ablatio reinae, or uveitis.
Lipotoxicity-related cardiac abnormalities can be reversed by PPAR g agonist therapy in type 2 diabetes patients.
1. Is an early surgery treatment strategy in neurological intact patients, with rheumatoid arthritis and radiological signs of craniocervical pathology, (cost-) effective when compared to prolonged conservative treatment? What is the time-dependant…
To determine whether a strategy of invasive treatment (relative to continued medical treatment) of patients with type 2 diabetes mellitus, mild symptoms of stable angina pectoris, and documented myocardial ischemia lead to a decrease in cardiac…
The purpose of this study is to evaluate the efficacy of oral ibandronate (versus placebo) added to the standard radiotherapy regimen for painful bone metastases to reduce pain, to reduce the need of analgesics, and to reduce skeletal-related events…
Tray application of 0.12% chlorhexidine gel-toothpaste has more than 15% better effect on ¡®de novo¡¯ plaque accumulation compared to tray application of regular toothpaste in a 3 day non-brushing model.
Pediatric physical therapy is effective in asymmetry in infancy, especially to positional preference, deformational plagiocephaly and natural course of asymmetrical motor development, established by plagiocephalometry, range of motion tests and…
Adding amantadine to the standard anti-HCV treatment can improve sustained response rates in chronic hepatitis C.
The degree of TH1-skewing by mycobacteria is controlled by NRAMP1 gene polymorphisms and related to the degree of inhibition of TH2-mediated disease.
Due to tumoricidal effect of PDT , it is expected that the central bile ducts remain free from tumor and so better and prolonged drainage can be achieved leading to beter QoL and survival.
1. To develop (cost-) effective implementation strategies which are feasible in daily practice; 2. To test the guidelines in a multicentre effectiveness trial; 3. To develop general quality indicators with appropriate measuring tools for diagnostic…
Low molecular weight heparin plus aspirin reduces the recurrence of preeclampsia and/or small for gestational age infants before 34 weeks gestational age in women with documented thrombophilia with a history of preeclampsia and/or small for…
Nebulised DNase has a decreasing effect on the duration of a hospital admission in infants admitted with an RSV-bronchiolitis.
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A two month distraction period results in similar clinical beneficial effects as a three month distraction period.
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