364 resultaten
We expect that treatment with azelastine/fluticasone propionate will decrease exercise tolerance limitation and will improve quality of life.
We expect that metformin in combination with lifestyle interventions reduces Antipsychotic induced Weight Gain compared to placebo in combination with lifestyle interventions.
Antidepressant medication does not add any effect to usual consultations by general practitioners in patients with minor and mild-major depression.
Performance of the Aeonose™ as a diagnostic tool to detect lung cancer: an external validation study
Primary Objective: To investigate the diagnostic performance of the Aeonose™ to distinguish breath of subjects suspected for lung cancer who are truly diagnosed with lung cancer from subjects suspected for lung cancer in which this diagnosis is…
The use of higher field strength MRI-scanners will improve the detection of (small) structural brain lesions in patients with focal drug-resistant epilepsy, potentially resulting in better seizure outcome after resective epilepsy surgery.
Sickle cell disease (SCD) is a devastating inherited hemoglobinopathy, characterized by hemolysis, vaso-occlusive crises and organ damage resulting in reduced life expectancy. Oxidative stress is a major pathophysiological factor in SCD playing a…
First we have to define its association with current objective inflammatory parameters and its quality to sense small (subclinical) changes in a short treatment period. If this quality exists, than the Handscan might be a new tool for objective and…
The purpose of this study is to evaluate toxicity and oncologic outcomes of MRI-guided focal salvage high-dose-rate brachytherapy (HDR-BT). In earlier studies, it was shown that focal salvage HDR-BT is feasible and results regarding toxicity are…
The degree of vulnerability (fragility) negatively impacts self-care, quality of life and their mutual influences in elderly patients with chronic heart failure, and the relationship with hospital (re) admission within one year.
It is hypothesized that the benefits of treating to target in early RA and UA, which were evident after 5 (IMPROVED study) and 10 (BeSt study) years as limited joint damage progression, good functional ability and (in BeSt) normalized survival at…
A nursing nutrition intervention improves protein and energy intake and performance based on hand grip strength compared to usual care.
We hypothesize that anxiety symptoms worsen after follow-up imaging compared to patients baseline anxiety levels.
Closing wedge osteotomy with plate fixation only will result in earlier mobilisation and better one year results considering pain and function then staple and cast fixation.
We hypothesize that in preterm infants with a gestational age below 34 weeks a low threshold intervention (progressive PHVD with a ventricular enlargement above the 97th centile for gestational age according to Levene and a diagonal width…
A self-management programme guided by doctors and a specialist asthma nurse through information and communication technology will improve asthma related quality of life in a cost-effective way.
Efficacy of minimal intervention strategy (isolated training of the lumbar extensors) with the use of a control group receiving usual care.
The use of preventive medication will lead to about 50% reduction of the symptomatic use of Nitroglycerin spray sublingual
We hypothesized that, in high PD-L1 expressing patients with high tumor burden, the combination of pembrolizumab with platinum-based chemotherapy will result in a higher tumor response, and possibly in a better progression free and overall survival…
De novo Parkinson's patients already present with declined driving ability at time of diagnosis, compared to age- and sex matched healthy controls.