19 resultaten
Approximately 1/3 of persons with IGT develops type 2 diabetes mellitus in 5-10 years time. Acarbose is an alpha-glucosidase inhibitor decreasing post-prandial glucose levels, without the risk of hypoglycemia. The prevention of diabetes with…
The primary objective of the study is to examine whether the WhiteTeeth app used by orthodontic patients aged 12 to 16 improves oral health behavior and oral hygiene. Primary outcomes of this RCT are dental plaque levels, gingival bleeding upon…
•To investigate the safety and tolerability of multiple ascending oral doses of DNL104 in healthy subjects •To characterize the pharmacokinetics (PK) of DNL104 in plasma and measure the trough concentrations of DNL104 in CSF. •To Explore the…
Modulation of phosphate intake can affect the antiproteinuric efficacy of RAAS-blockade therapy in CKD patients
Assess the safety and tolerability of single ascending IV bolus doses of ABP-700
We hypothesize that tACS can enhance brain synchronization between frontal and parietal regions, thereby improving cognitive functioning in MS patients.
The implementation of antimicrobial coatings in health care results in an improved hygienic environment to support patient recovery and lowers the risk of a health care associated infection.
-We expect that the youth who receive an active CBM training on top of care-as-usual show a greater reduction in cannabis or alcohol misuse at follow up when compared their general population peers. -We expect that CBM training works by reducing…
It is hypothesized that chicken eggshell membrane is effective in the regeneration of cartilage and/or immunomodulation (oral tolerance), and as such positively affects pain and stiffness in joints commonly affected in arthritis
We hypothesize that Iberogast reduces heartburn in patients with functional dyspepsia through an effect on both oesophageal hypersensitivity to acid and on the incidence of reflux episodes.
To determine the role of 5-HT2 and 5-HT1A receptors in learning and memory. It is expected that: 1. An acute dose of MDMA will produce impairments on laboratory measures of learning and memory; 2. MDMA-induced memory impairment will be reversed…
Onlay and sublay mesh reinforcement after midline laparotomies in patients with an increased risk for the development of incisional hernias (IHs) resulted in less IHs compared to patients that received the conventional closure technique at two years…
Primary Objective: Investigate the effect of modafinil (200 mg) and caffeine (300 mg) on vigilance in low, medium and high caffeine consumers during the circadian trough in order to determine: - To what extend vigilance during the circadian trough…
Cabozantinib improves overall survival in patients with hepatocellular carcinoma compared with placebo
1.We expect participants in the experimental condition to show a reduced gmbling behaviour 2. We expect participants in the experimental condition to show a decrease in approach bias towards gambling cues, and weaker approach implicit associations…
Varenicline reduces craving to cocaine and/or impulsivity in human cocaine users.
Hypothesis 1: We expect to find an approach bias in forensic sexual offenders and in sexual addicts. Hypothesis 2: The proposed intervention will cause a decline in approach bias in forenisc sexual offenders and sexual addicts, compared to the…
•Bicruciate preserved tibia tray for TKA is at least as efficient and safe as the conventional tibia tray for TKA with elimination of the ACL. •TKA with the use of Signature™ alignment guide is at least as efficient and safe as TKA with the use of…
The main hyothesis of the experiments is that a dual action antidepressant (duloxetine) modulates functions in specific brain areas involved in the processing bias of emotional stimuli in the context of neutral versus depressed mood.