377 resultaten
The primary objective is to determine whether JWH-018 can be safely administered in healthy volunteers in doses up to 3 mg. Therefore participants will be continuously monitored by a medical doctor and vital signs, laboratory clinical safety and…
To study if a Mediterranean diet (MD) followed by lean donor fecal microbiota transplantation (FMT) has synergistic superior beneficial effects on peripheral insulin sensitivity and (small) intestinal microbiota composition as compared to…
We hypothesize that treatment with peppermint oil will lead to a greater symptom (especially abdominal pain) reduction in IBS patients compared to placebo. This will lead to a higher total percentage of responders (as defined by FDA/EMA…
The administration of propranolol will inhibit the increase in dermal blood flow (DBF) induced by capsaicin application.
this study hypotheses that EEG does not predict future seizures. If correct abandoning routinely EEG will lead to a reduction in health costs and patient/family burden. Furthermore, neurocognitive development will be investigated two years after…
Treatment with rhEPO has no effects on performance parameters measures by exercise tests.
Extension of SAD PK/PD Model, confirmation of SAD PD effects
1) In both younger older adults, 3 days of disuse via unilateral lower-limb immobilization will result in muscle atrophy and coincide with decreased rates of “cumulative” muscle protein synthesis (MPS) during disuse. 2) In both younger and older…
PK and PD effects of JNJ-61393215
A single exercise bout with a minimum duration of 10 minutes and a moderate to vigorous intensity level has small but positive effects on cognitive performance in children. These acute effects on cognitive performance are thought to be mediated by…
Patients treated with ziprasidone reveal fewer negative symptoms on the PANSS negative symptoms sub-scale and/or better scores on the CGI therapeutic effects sub-scale (CGI-TE) than patients treated with low-dose conventional antipsychotics (5 mg/…
Because of the impact of chronic abdominal pain in children and the long term prognosis with impressive consequences for the life of the patients and for the society, it is important to aim at optimal therapy. Standard therapy is rather ineffective…
Divergent Low Level Laser Therapy as novel treatment for oral mucositis in pediatric cancer patients
What is the effect of divergent LLLT on the number of days of mucositis > grade 1?
Treatment of fear of falling in hip fracture patients in GR, using the FIT-HIP intervention, will lead to reduction of fear of falling and therefore to an improvement of mobility function (gait and balance), in comparison to patients with fear of…
This study investigates the hypothesis that regional anesthesia provided by wound catheter infusion (WCI) with ropivacaine reduces pain postoperatively (as measured with COMFORT behavior scale and NRS Pain scores) and leads to a morphine-sparing…
The use of a GDFT protocol during liver surgery instead of the widely used LCVP regimen has no influence on blood loss.