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It is postulated that the investigational treatment has superior efficacy based on observations of longterm remissions in a number of patients, although this has to be balanced against potentially higher toxicity.
Enzyme therapy with recombinant human alpha glucosidase results in prolonged survival; improvement or stabilisation of cardiac hypertrophy and function, improvement or stabilisation of pulmonary function and improvement or stabilisation of muscle…
Due to tumoricidal effect of PDT , it is expected that the central bile ducts remain free from tumor and so better and prolonged drainage can be achieved leading to beter QoL and survival.
Low molecular weight heparin plus aspirin reduces the recurrence of preeclampsia and/or small for gestational age infants before 34 weeks gestational age in women with documented thrombophilia with a history of preeclampsia and/or small for…
In a randomized controlled study comparing psychiatric consultation with care as usual by the company physician, patients will improve in the intervention group in terms of duration of sick leave, general functioning and quality of life.
Immediate PCI in patients with NSTE-ACS is superior to early PCI with respect to 30-day size and occurrence of (non STE) myocardial infarction, death and revascularization.
The hypothesis to be tested is that the outcome in arm B is better than in arm A.
10 Gy additional boost to the tumor bed will yield an increase in local control at 10 years from 88% to 93%, with still acceptable cosmesis.
Test in a phase III randomised study whether an improvement of loco-regional control can be obtained with accelerated postoperative radiotherapy (66 Gy in 5 weeks) as compared to conventionally fractionated radiotherapy (66 Gy in 7 weeks) in…
There are predictive markers of treatment response (or non-response) at baseline or during early beginning of treatment?
Early induction of labour being an effective intervention e.g. for the prevention of neonatal neurologic morbidity for fetus with established disproportionate intauterine growth retardation.
1. After treatment, patients of the experimental group will show less depression; 2. After treatment, patients of the experimental group will show better quality of life; 3. After treatment, patients of the experimental group will show less…
Clients in a consumer-driven program for recovery, empowerment and experiential expertise will have better outcomes on self-efficacy and empowerment than clients on a waiting list for the program.
1. What are the effects of a minimal intervention given by a nurse and a more intensive psychological intervention on managing fatigue during active treatment of cancer compared to no intervention? Will a minimal intervention be sufficient or is a…
The treatment of depression in primary care: efficiency of computerised cognitive behaviour therapy.
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A self-management program including self-treatment of exacerbations, leads to a reduction in the severity and duration of exacerbation compared to a similar self-management program without these self-treatment guidelines in hospital out-patients…
In MMC-children treated with CIC, the incidences of significant bacteriuria and pyelonephritic episodes are only slightly smaller in the group of subjects treated with LDCP compared to the group without LDCP.
This study aims to evaluate the baseline GH status, body composition and insulin sensitivity in (pre)pubertal short children born SGA. It also evaluates the effects of GH treatment on GH levels, body composition and insulin sensitivity. Furthermore…
Does the use of alternatives to allogeneic blood (erythropoietin or reinfusion of autologous shed blood intra- and/or postoperatively) for patients undergoing elective total knee- or hip replacement surgery lead to continuous sparing of allogeneic…