193 resultaten
In this explorative study we will examine the impact of daily ischemic preconditioning on brachial artery endothelial function (measured as FMD%, before and after IRI) during 7 days in the non-shunt arm and lower limb in patients with end-stage…
Different studies have shown that a hunter-gatherer type diet is effective in improving glucose regulation and lipid profile. I want to investigate if the hypothese that this type of diet also reduces the number of physical and psychological…
This study aims to assess the efficacy and safety of induction and consolidation therapy with Carfilzomib, Pomalidomide and Dexamethasone in subjects with relapsed or refractory multiple myeloma (MM) after prior first-line treatment in the EMN02/…
- Hypothesis#1 efficacy We hypothesize that a quick onset, and a predictable dose-response, good adjustability of analgesia can be achieved with inhaled ketamine. Hypothesis#2 safety Inhalation of nebulized ketamine might lead to a fast onset of…
Our hypothesis is that high-dose, pulsatile sorafenib may exhibit improved efficacy with an acceptable toxicity profile compared to standard continuous dosing. AUC escalation cohorts are used instead of the conventional dose escalation cohorts,…
Primary aim: 1. To investigate whether differences exist in the mitochondrial energy generating capacity of skeletal muscle of statin users with SAMS compared to statin users without SAMS and controls (non-statin users). Secondary aims: 2A. To…
The RAINBOW study: Rheumatoid Arthritis ImplemeNtation of Biological dose Optimization in real World
We hypothesize that a multifaceted implementation strategy can stimulate the use of tight control and bDMARD dose optimization in clinical practice, measured by decreased bDMARD use and non-inferiority on disease activity at 18 months.
1) The knowledge of the legal aspects of health care and medical negligence/errors among medical residents is larger in the intervention group than for the control group 2) The flipped classroom model is effective as a teaching method in post…
Our hypothesis is that receiving written and audio-visual patient information will reduce the frequency and severity of post-concussion symptoms in patients with MTBI.
By offering a screeningstool for OSAS in the first line (general practitioners), it is expected that diagnosing OSAS becomes easier, faster, cheaper, more efficient, patientfriendly, and is also accessible to a wider audience.
First objective: To study the influence of mucositis on the absorption of sublingually delivered fentanyl (Abstral ®) in head and neck cancer patients treated with chemoradiotherapy. Secondary objectives: to study the influence of xerostomia on the…
The doctor-patient-relation is a powerful and important tool in the complex care for patients with (chronical) MUS.
Inhalation of once daily double dose of inhaled tobramycin targeted to the small airways by the Akita (1x 300 mg instead of 2x 150 mg) is more effective in reducing small airways obstruction compared with standard of treatment: twice daily…
We hypothesize that: (1) GPs who receive the ASBI implementation program will increase screening and brief intervention delivery rates relative to GPs in the control condition; (2) GPs involved in the ASBI implementation program will have a…
Increasing age is associated with a decrease in step length, gait speed, and mobility. Gait speed predicts numerous clinical conditions, including independence and mortality. A variety of exercise interventions are highly effective in maintaining…
To determine the effectiveness of guided CBT compared to care-as-usual in treating insomnia in the general practice.
First, non-invasive diagnostic tools can optimize the diagnostic strategy, in order to minimize the number of invasive diagnostic procedures. Second, invasive imaging of the pulmonary artery can further differentiate the mechanisms involved in PH…
The aim of this study is to compare clinical outcomes and cost-effectiveness of two procedures for skin sparing mastectomy with implant reconstruction in a randomized clinical trial. The currently preferred two-stage breast reconstruction with…
Protein feeding prior to surgery enhances muscle and bone protein synthesis rates in the post-prandial period when compared to the non-feeding condition in older patients undergoing total hip arthroplasty.