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Reducing breathing spells in preterm infants: air flow versus caffeine

Low-Flow is non-inferior in reducing apneic spells to caffeine.

Wobble - Het Wiebelkinderen Onderzoek naar Betere Breinprestaties en LeerEffecten

1. Using a wobble cushion and tangle will lead to improved performance on a math test, reading comprehension test and on a sustained attention test for children with more problems with sensory information processing (both low and high threshold) in…

Identification of Patients with COPD with a Poor Prognosis and Implementation of Proactive Palliative Care

The study consists of an indicator study and an intervention study. 1. Indicator study We expect that the set of indicators will have discriminative power to predict readmission within 8 weeks and/or death within 1 year for patients hospitalized…

Compare fine motor skills of children: Visual impaired and normal vision.

Fine motor skills of visually impared children will be slower and less accurate compared to normally sighted peers.

A clinical trial to test if Ruconest causes immunological reactions in healthy volunteers who are allergic to cow's milk and/or rabbit.

A SPT has been proposed to screen subjects with increased risk of hypersensitivity reaction to Ruconest. Subjects with RA and subjects with clinical CMA have an increased risk of hypersensitivity: although cow's milk proteins differ from rabbit…

Alcohol and cannabis.

It is hypothesized that in the population of frequent cannabis users, cross tolerance will have developed for the effects of alcohol, and that therefore the behavioral effects after alcohol will be less when given in combination with cannabis.

Kwaliteit van leven na plaatsing van een knie prothese bij dag-opname.

It was hypothesized that there would be no difference in quality of life between both pathways.

Functional outcome of clubfeet using a new type of brace.

In our practice we devised a fully dynamic brace (Dynko brace). Our believe is that the dynamic component which allows rotation and walking/kicking movements will increase the comfort in wearing and by this increase compliance. Secondary we believe…

B-vit in the joint

Synovial fluid levels of high dosed oral intake Vitamin B3 are at least 10% of plasma levels We envision that NAM maintenance treatment, when combined with established immunosuppressive treatment, could help restore the immunological balance and…

A study looking at 2-Iminobiotin as treatment for newborn children suffering from insufficient oxygen supply to the brain in addition to standard treatment with cooling.

To explore the short term safety and tolerability of 2-IB and the pharmacokinetic profile of 2-IB when given on top of therapeutic hypothermia

Use of an electronic patient decision aid to support Shared Decision Making and treatment planning in psychotic disorders.(NL: Samen Keuzes Maken).

We expect the intervention group to be more satisfied with the treatment planning process compared to the control group.

Patient satisfaction following education in patients with breast cancer. WEBapplication versus the usual verbal information
WEB-CAM trial II.

The influence of the use of a web-based application on the patient satisfaction by eduction to patients with breast cancer.

Efficacy in DIabetes treatment: Surgery Or coNventional: the EDISON-trial.

The prevalence of type 2 diabetes (DM2) in the Netherlands has increased dramatically in recent years and is expected to rise to 1.3 million persons in 2025. Most DM2 patients are overweight and 30-50% have obesity (body mass index > 30 kg/m2…

Severe Asthma with comorbid BronchiEctasis: response to BIOlogical therapy

To evaluate the real-world use and effectiveness of anti-IL-5 biologics (mepolizumab, reslizumab and benralizumab) in patients with severe eosinophilic asthma with comorbid bronchiectasis

Evaluation of Optimized ROM and Shared Decision making

Training therapist in optimized ROM (Feedback Informed Treatment) and Shared Decision Making will result in less drop-outs, better outcomes, better patient experience and more favourable attitude ot therapist towards Routine Outcome Monitoring

Shared care for patients with chronic kidney disease in nephrology and general practice.

The hypothesis is that patients with chronic kidney disease will meet treating goals better when they are treated in a shared care model by a general practitioner, a practice nurse and with online consultation of a nephrologist.

Grip op je dip online: development and effectiveness.

The course of Gripopjedip is more effective in terms of depressive symptoms, sense of mastery and symptoms of anxiety than a waitlisted group.

Metabolic effects of Growth Hormone

The hypothesis is that rhGH treatment in children with KS results within 6 weeks in a change of metabolism recognizable as an increase of total energy expenditure (TEE). This change in metabolism can be used as a predictor of growth response in the…

Late Effects and Follow up after pediatric hematological stem cell transplantation and cell therapy (LEEF)

Better knowledge and awareness of Late Effects after pediatric HSCT for non-malignant diseases will lead to optimal screening procedures after HSCT that may eventually contribute to reduce transplant-related long term morbidity and mortality and…

Effects of CPAP on the underlying mechanisms of sleep apnea

The hypothesis is that using CPAP decreases the severity of the underlying mechanisms in sleep apnea patients.