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1. To assess the safety and tolerability of different doses of a single IV injection of OTL-038 2. To assess the efficacy of ascending doses of a single IV injection of OTL-038 in detecting ovarian, renal cell or endometrial cancer during surgery by…
Rationale: Irregular menstrual cycles during puberty have been considered part of development, explained by incomplete maturation of the hypothalamic-pituitary ovarian axis. A distinction between developmental and pathological causes of abnormal…
The detection rate of leptomeningeal metastases with the CellSearch technique is higher compared to cytology.
Compared to usual care, PPEP4All will cost less, lead to better quality of life, fewer psychological symptoms, more resilience, and less chronic disease burden for both patient and partner.
We hypothesise the following; 1. Lowering the incidence of contrast induced nephropathy is possible when the diuresis is increased up to >300 ml/hour during the intervention (PTA) and is continued up to 4hours after the revascularizing…
The aim of this study is to examine whether the implementation of a redesigned intake process using e-health is effective compared to the intake as usual without an e-health intervention. The first hypothesis is that using e-health in a new intake…
1.Potentially transplantable high risk donor liver grafts can be distinguished from non-viable high risk donor liver grafts using NMP. 2.DHOPE, prior to ex situ viability assessment, increases the odds of a high risk donor liver graft to be…
To assess in a randomized comparison the effect of Ibrutinib added to 10-day decitabine treatment on the cumulative CR/CRi rate after 3 cycles. To assess the safety and tolerability of Ibrutinib added to 10-day decitabine treatment for AML (…
The use of motivational counselling and inclusion of a written health plan in an occupational health examination will improve personal work resources and work ability at 12 months follow-up
Treatment of fear of falling in hip fracture patients in GR, using the FIT-HIP intervention, will lead to reduction of fear of falling and therefore to an improvement of mobility function (gait and balance), in comparison to patients with fear of…
Children in the intervention condition will consume (a) more water and (b) less sugar sweetened beverages after the intervention compared to the control condition.
Reveal common mechanisms of compulsivity in OCD and GD and disorder specific characteristics of aspects that have been related to compulsivity: confidence in relation with preference for risky and ambiguous behavior, and (negative) outcome…
During the cooling by a cold cap, the scalp is cooled to 4oC for a long period of time (30 minutes prior to start and up to 45 minutes after the infusion of paclitaxel). This could be of influence on the body temperature. Pharmacokinetics and…
Exploratory study to develop hypotheses
We aim to test the accuracy of Western gastroenterologists in differentiating T1 CRCs from its precursor lesions and subsequently in estimating invasion depth
Determining maximal tolerated dose hydroxy-ureum in combination with dose intense temozolomide in patients with recurrent glioblastoma
A decision aid about postoperative epidural analgesia will improve patients' knowledge.
To determine the influence of the fatty beverage Cow’s milk on the systemic exposure (AUC) to erlotinib in patients with or without concomitant use of a PPI.