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The hypothesis is that immunization against VEGF will circumvent the specific drawbacks of the current anti-VEGF treatment modalities. The primary objectives of this study are to investigate the safety and tolerability of hVEGF26-104/RFASE and to…
18F-FDHT PET/CT is expected to be a predictor of response in patients with metastasized castration-resistant prostate cancer to be treated with enzalutamide
This is a clinical trial in the home environment of 60 epilepsy patients to investigate the sensitivity and positive predictive value of a multimodal sensor system (‘LivAssured’) for the detection of nocturnal motor seizures.
The aim of the study is: (1) observational, i.e., to assess and describe the responses of patients and volunteers to a variety of different stimulation paradigms; (2) diagnostic, i.e., to assess whether specific tests are possibly diagnostic for…
The percentage of successful PIV insertions at the first attempt in newborns will increase with the Veinviewer® and/or Astodia®, two vascular imaging devices
A comprehensive multisiciplinary lifestyle intervention program reduces the risk of recurrent cardiovascular events in patients who have suffered an acute coronary syndrome.
Mindfulness training as well as medication will reduce symptoms of attention, hyperactivity and impulsivity, not only directly after training but also at follow-up.
The use of the Claret device in TAVI procedures reduces the incidence of ischemic cerebral lesions (detected by DW-MRI)
To implement the Enhanced Recovery After Surgery (ERAS) programme in elective gynaecological surgery on large scale in an (cost) effective manner is challenging. The traditional used breakthrough method for health care improvement on large scale…
The aim of the study is to investigate the interrater and intrarater reliability of the MicroFET5 inclinometer for movements of the lumbar spine specific flexion, extension and lateral flexion. The hypothesis is that the MicroFET5 inclinometer is a…
1. Patients that received cognitive behavioral therapy prior to bariatric surgery show better weight loss maintenance at the post treatment measurement and follow-up measurements after one, three, and five years after the operation, than patients…
The programme at Work, will result in a significant increase of work-related self-efficacy in comparison to the usual care and a higher percentage of work participation.
Bone mineral density decline can comparably be estimated by achilles as with DXA.
Baseline resting levels of cardiac troponin have been shown to be a predictor fur future cardiovascular events and mortality. We hypothesize that the exercise induced increases in cardiac troponins may be a superior predictor for survival and CVD…
Fentanyl is a strong opioïd and is highly lipophilic. Fentanyl pharmacokinetics are characterised by large inter- and intrapatient differences, which may have serious consequences for the activity and toxicity profile of this drug. The use of…
Our primary hypothesis is that IRE will add a maximum of 28% clinically relevant complications, defined as Clavien-Dindo score 3 or higher, to the current 28% of complications associated with palliative treatment.
ICG combined with 99Tc-Nanocoll can be used as fluorescent tracer in sentinel lymph node mapping in vulvar cancer patients.
medication reconciliation by pharmacists decreases the amount of medication transfer errors in patients admitted to the intensive care
Use of the GEM microvascular anastomotic coupler is feasible in coronary artery bypass procedures with the extended radial artery technique and the coupler anastomoses is patent after 3 months.
The study consists of an indicator study and an intervention study. 1. Indicator study We expect that the set of indicators will have discriminative power to predict readmission within 8 weeks and/or death within 1 year for patients hospitalized…