110 resultaten
To determine immunogenicity of NIP vaccines in preterm infants when vaccinated according to the current Dutch NIP schedule and with rotavirus vaccine following the RIVAR study. To unravel the mechanism of immature host responses and interaction with…
We test the effect of 1) a verbal suggestion providing a strong under prediction of the pain intensity of upcoming heat stimuli as compared to 2) a verbal suggestion providing a correct prediction of the intensity and 3) a verbal suggestion…
Determining the overall diagnostic performances of WBC scintigraphy, FDG-PET/CT and MRI in trauma patients with suspected fracture-related infections and establish the most accurate imaging strategy for diagnosing (or excluding) fracture related…
Performance of the Aeonose™ as a diagnostic tool to detect lung cancer: an external validation study
Primary Objective: To investigate the diagnostic performance of the Aeonose™ to distinguish breath of subjects suspected for lung cancer who are truly diagnosed with lung cancer from subjects suspected for lung cancer in which this diagnosis is…
The purpose of this study is to evaluate toxicity and oncologic outcomes of MRI-guided focal salvage high-dose-rate brachytherapy (HDR-BT). In earlier studies, it was shown that focal salvage HDR-BT is feasible and results regarding toxicity are…
It is hypothesized that the benefits of treating to target in early RA and UA, which were evident after 5 (IMPROVED study) and 10 (BeSt study) years as limited joint damage progression, good functional ability and (in BeSt) normalized survival at…
We hypothesize that anxiety symptoms worsen after follow-up imaging compared to patients baseline anxiety levels.
Ultimately, the implementation of a geriatric assessment and a national registry in pre-dialysis care for older patients with ESRD will provide insights in determinants of adverse outcomes, inform and benefit decision making trajectories for…
Using newly developed population pharmacokinetic models for DDAVP and VWF-containing concentrate in von Willebrand disease (VWD), clotting factor levels (FVIII and VWF:Act) after dosing of DDAVP or VWF-containing concentrate can be reliably…
1. Using a wobble cushion and tangle will lead to improved performance on a math test, reading comprehension test and on a sustained attention test for children with more problems with sensory information processing (both low and high threshold) in…
The hypothesis is that the Manometric brace is superior to conventional plaster braces in terms of patient satisfaction, compliance and patient preference. For pain and hand function, no superior outcomes are expected for the Manometric brace…
0-hypothesis: no clinically relevant difference in clindamycin exposure (AUC/MIC) in overweight patients using 70 kg as a reference body weight
Patients have a better recovery after laparoscopic sterilization under conscious sedation compared to general anesthesia as measured with the QoR-40 one day after surgery.
This study will investigate the effect of different price and nudging strategies on food purchasing behaviour in a virtual supermarket setting among Dutch adults with both a low and high socio-economic status. Our hypothesis is that pricing…
The proposed study seeks to investigate the effectiveness of a booklet self-help program in the treatment of depressive symptoms among people living with HIV. We will compare the booklet self-help program with an attention only control condition. In…
Compared to placebo treatment with low dose amitriptyline or mirtazapine during 16 weeks will improve subjective insomnia in insomnia disorder patients in general practice.
Contralateral exploration during unilateral inguinal hernia repair in children younger than six months reduces the incidence of contralateral inguinal hernia and decreases the number and total duration of operations, anesthesia time and hospital…
We hypothesize that 18F-FDG is a valide marker for metabolic activity in adipose tissue and even more pronounced in type 2 diabetes.