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The main objectives of this study are: • To gain insight into the effectiveness of the Healthy Working Approach on need for recovery in elderly care workers over one year. • To gain insight into the process of implementing the Healthy Working…
The lifestyle program will improve the quality of life and lifestyle behavior, and will decrease the healthcare utlization, comorbidity and cancer recurrence rates.
Gastric fluid volumes in patients with a 6-4-0 pre-operative fasting regime are comparable to patients with a 6-4-2 pre-operative fasting regime
We hypothesise that standard anaesthetic management guided by mitoPO2 monitoring to optimise tissue oxygenation, using conventional measures, results in higher tPO2 during surgery and, therefore, a higher mean mitoPO2 over time.
The main clinical challenge remains to identify patients who may benefit from aggressive local treatment (stereotactic radiotherapy, SBRT) of soft tissue oligometastases: for which patients can systemic treatment be postponed? Patients who are…
European randomised controlled multi-centred implementation trial amongst 24,000 individuals, at high risk for developing lung cancer, evaluating whether it is safe to have risk-based less intensive screening intervals after a negative baseline CT.
Deferiprone rescues oligodendrocytes in children with PMD and leads to improved myelination and motor function.
We hyopthesize that in SCCH patients 3-monthly pamidronate decreases locally increased bone turnover (measured by Na18F-PET scans) and thereby decreases pain, and leads to improvement in shoulder girdle function, quality of life, physical and work…
Patientes with mental disorders will experience more often sexual problems and a need for help for these problems compared to healthy controls
Primary: To explore the pharmacokinetics of insulin aspart after pulsed intra-vaginal delivery using the MedRing and after subcutaneous injection in women with T1DM. Secondary: To assess the safety and short-term tolerability of insulin aspart after…
- Hypothesis 1 (H1): MEG peritumoral broadband power is relatively stable in the context of stable disease and pseudoprogression in GBM patients. - Hypothesis 2 (H2): MEG peritumoral broadband power increases significantly when progression occurs…
There is no difference in information retention in patients when educated preoperatively by telephone or by video.
1. There will be a significant improvement in cognitive control, attention bias and memory bias performance after completion of the selected training module in the active vs. control training. 2. Rumination and depressive symptom severity will…
It was hypothesised that the smartphone-administered eQoR-15NL has comparable measurement properties (i.e. measurement equivalence) compared to the paper-based QoR-15NL questionnaire.
VRT-SOAP is an effective treatment for improving quantity and quality of social contacts, leisure activities and social participation in young people with a psychotic disorder
We hypothesize that the use of the CD40 agonist mitazalimab (also known as JNJ-64457107 and ADC-1013) may convert pancreatic adenocarcinomas into immunological hot tumors by T-cell-dependent and T-cell-independent mechanisms. Dendritic cell therapy…
Gait quality improves after cruciate-retaining TKA, but will still be abberant compared to healthy, age-matched controls. We will quantify the quality of gait using different metrics related to the specific testing condition. As a primary hypothesis…
We expect that the test characteristics of saline infusion sonography will be higher than the test characteristics of the transvaginal ultrasound. We expect that the saline infusion sonography is less painful and has a lower complication rate than…
Secondary attack rates of SARS-CoV-2 will differ when stratified for the age of the index case.
Current antibiotic treatment with beta lactam do not meet pharmacodynamic targets in pediatric intensive care unit patients