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We hypothesize that the CPA Talking-with-children-intervention will have a beneficial effect on the mental health and quality of life of maltreated children. We expect that children who participate in the CPA investigation (CPA Talking-with-…
Patients who will train with the SCRIPT-system will have similar or improved arm and hand function in comparison with the patients who receive conventional arm and hand exercises.
The aim is to investigate the effects, costs, and feasibility of an evidence-based professional-directed implementation strategy to implement the Dutch peri-operative guidelines, i.e. to achieve a higher adherence to these guidelines. It is…
Use of IBD-live for 1 year: 1. Reduces the relapse rate from 40% to 25%; 2. Increases quality of life (assessed with the IMPACT-III questionnaire).
Patients with a BMI > 30 kg/m2 in the ICU have a higher incidence of pressure ulcers and wound infections in the ICU compared with patients with a BMI 18-25kg/m2. They develop them sooner during admittance and the severity and time to…
The aim of the study is to determine whether cardiac output measurements obtained using APCO are comparable with those obtained using transpulmonary (advanced FloTrac software) and intermitted bolus thermodilution cardiac output in critical ill…
Relative to the control condition of 'recall only' the experimental condition of 'recall + eye movements' will produce a reduction in both the 1) subjective vividness/emotionality of the mental image and associated recall-induced…
We hypothesize that in rheumatoid arthritis (RA) patients responding to adalimumab, with high adalimumab serum concentrations at least 28 weeks after treatment initiation: 1. Lowering the serum concentrations through dose interval prolongation will…
We hypothesize that in patients with severe corticosteroid dependent asthma Dabigatran etexilate will: 1. Reduce airway inflammation; 2. Improve asthma control and pulmonary function; 3. Reduce hypercoagulability in the airways.
For patients with severe symptomatic aortic valve disease, aortic valve replacement surgery is the treatment of choice. Two options exist: Mechanical and bioprosthetic aortic valve. The decision which valve type to choose is difficult, since in most…
The hypothesis is that an accurate history, conventional markers of sensitization, IgE antibodies in the serum and positive SPT, and more advanced techniques (MRAs and component resolved diagnosis (CRD)) might predict clinical allergy to cashew nuts…
The quality of human milk shows an association with the women's diet and lifestyle.
We developed an MRA with integrated accelerometer with which we plan to measure the therapy-effect of the MRA, the compliance and the position of the head of the patient.
Dietary inorganic nitrate supplementation will decrease O2 cost of exercise in patients with mitochondrial myopathy.
Electrical stimulation of the sympathetic pathways by cervical spinal cord stimulation increases cerebral blood flow.
Phase I: To investigate whether it is feasible to organise an international multi-centre pragmatic trial to study the value of individualised homeopathic add-on treatment using a semi-standardised algorithm in women with premenstrual disorders,…
Compared to a control group, the mindfulness group intervention is expected to result in: 1. A decrease in symptoms of psychological distress; 2. An increase in quality of life; 3. An increase in heart rate variability; 4. A decrease in blood…
Falls are common in elderly and often result in adverse consequences. The effectiveness of C-Mill training, i.e. treadmill walking with a specific emphasis on functional walking ability via constant and irregular gait modulations, obstacle crossing…
Mindfulness improves wound healing
In the PROHTECT-3B trial, we offer hrHPV testing on self-sampled (cervico-)vaginal specimens obtained by either a lavage device or a brush device. The respons rate of the two devices will be compared. Also, the user comfort and sensitivity and…