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Focusing on disease-modifying rather than etiologic mechanisms may accelerate the development of novel therapies and complement current research initiatives on causative mechanisms and curative therapies.
Education on guidelines, combined with quality targets within the accreditation procedure improves quality of antibiotic prescribing
We hypothesized a beneficial effect of IUI in couples with an isolated cervical factor. Furthermore we hypothesized that the post-coital test can identify those couples who would benefit from IUI without ovarian hyperstimulation.
1-2 intramuscular injections with 100 mg dexamethason in persons without arthritis but with elevated serum levels of rheumatoid factor and or anti-CCP will lead to a reduction in antibody concentrations after 6 months and possibly to a lower…
Different prevention strategies are used internationally to prevent Early-onset Group B haemolytic streptococcus infection (EOGBS). However, none of the preventive EOGBS strategies in place at present result in the complete prevention of EOGBS,…
Care providers are more likely to adhere to clinical practice guidelines when they receive guideline-based decision support by an electronic system.
In this study, we expect to decrease the number of referrals and repeat smears by immediately referring those women who are positive for hrHPV with mildly abnormal smears for colposcopically-directed biopsies. Thus, for the remaining women with BMD…
An upfront RBCT aiming at low-normal Hb levels will ameliorate anemia-caused tumor hypoxia-related resistance to chemotherapy before the start of chemotherapy and may decrease secondary anemia-induced endogenous release of cytokines like VEGF,…
Home DC-ECV in general population patients with an episode of symptomatic recurrent persistent AF, carried out by ECPs, is feasible, safe and is associated with reduced costs.
There is no difference between CT- and MRI-based Patient specific matched instruments for total knee arthroplasty
The primary objective of this study is to determine whether thrombectomy combined with ischemic postconditioning after PCI leads to a smaller myocardial infarction compared to standard therapy.
The purpose of this research is to acquire a better understanding of the pain experience and the recovery of children between 1.5 and 5 years old who underwent a tonsillectomy/adenotonsillectomy. Primary research question: What is the influence of…
Pre- and probiotics are able to change the composition of the altered intestinal microbiota that is found in allergic patients, indicating beneficial effects of these nutritional components in the prevention and treatment of allergic diseases. The…
Spinal anesthesia induces several alterations in normal brain processes. Firstly, loss of afferent information increases pain sensitivity. In our previous study on the effects of spinal anesthesia (P11.221) we showed that subjects felt more pain…
Induced hypothermia to 32-34 degree Celsius using NovathermTM with extracorporeal iLA-Activve MinilungTM allows for a reduction in minute volume ventilation needed for adequate gas exchange in patients with ARDS, with a concomitant decrease in work…
To determine if treatment with rhEPO reduces the need for top-up transfusions in neonates with red cell alloimmunization treated (with or without intrauterine transfusions).
Objective of the study: The research aims to 2 new forms of treatment for patients with comorbid PTSD as a result of multiple and repeated abuse in childhood to assess and compare Imaginary Exposure. The expectation is that these new forms of…
A 4 hour intervention period with the new disease-specific tube feed will result in a better plasma glucose profile as compared to an isocaloric standard tube feed.
Tamoxifen and endoxifen serum concentrations are linearly related to DBS concentration