30 resultaten
Primary aim: 1. To investigate whether differences exist in the mitochondrial energy generating capacity of skeletal muscle of statin users with SAMS compared to statin users without SAMS and controls (non-statin users). Secondary aims: 2A. To…
In line with a previous pilot study we hypothesize that 3MDR will significantly decrease PTSD symptom severity in treatment resistant veterans with chronic PTSD in comparison with treatment as usual.
Prosody, both linguistic and emotional, is essential in the acquisition and usage of language and socio-emotional development, but it proves difficult for CI users because of their relative inability to hear spectral and, to a lesser degree, dynamic…
We expect maternal hyperoxygenation in the presence of fetal distress during labor to reduce abnormalities in the fetal heart rate tracing and to reduce the need for assisted birth or a emergency caesarean section without severe maternal or fetal…
Children participating in daily sport classes will attain higher academic achievement than their counterparts who participated in the standard physical education classes incorporated in the school curriculum (1 hour/week).
It is hypothesized that implementation of the MASS protocol in IVE schools will increase the chances of obtaining a degree and a better chance of work employment in later life. An adequate approach to absenteeism using the MASS protocol at IVE…
Delegation of clozapine monitoring tasks to a Nurse Practitioner (condition A) is at least as safe as Treatment As Usual: physicians perform monitoring tasks themselves (condition B).
The hypothesis is that minimal invasive surgical ablation through video assisted thoracoscopic surgey as a primary treatment in patients suffering from (longstanding) persistent atrial fibrillation is superior to transvenous catheter ablation
Background: Multiproblem young adults (between ages 18 and 27), characterized by a variety of severe psychosocial problems, comprise a societal challenge with high priority on the political agenda, both nationally and internationally. However, so…
Treatment of patients diagnosed with laryngeal cancer with total laryngectomy with or without (chemo)radiation often induces speech, swallowing and shoulder complaints. Speech, swallowing and shoulder exercises may prevent or diminish these…
Rates of neuropsychiatric symptoms are extremely high in institutionalized people with young-onset dementia. Neuropsychiatric symptoms are associated with reduced quality of life of residents and higher caregiver burden. Therefore, the Grip care…
1) The TTCM is effective in terms of HR-QOL, pain, functional status, patient satisfaction and perceived recovery compared to regular care in trauma patients with at least one fracture. 2) The TTCM is cost-effective from a societal perspective (…
One-stop-shop concept, using real-time in vivo reflectance confocal microscopy as diagnostic tool is non-inferior to standard of care in the surgical management of new primary basal cell carcinoma
Diabetes Mellitus type 1 is an autoimmune disease that cannot be cured. Complications due to insufficient regulation of blood glucose by exogenous insulin reduce life expectancy and quality of life. Proinsuline-loaded Tolerogenic DCs are induce…
Within the forensic mental health services, a demand exists for the development of focused interventions and/or guidelines for the treatment of specific criminogenic factors. For sex offenders, deviant sexual arousal is such a criminogenic factor.…
Multiproblem families (MPFs) provide a huge public health challenge because of socio-economic deprivation, psychosocial problems, parenting problems, domestic violence and rule-breaking behaviour. Therefore, there is a strong need for evidence-based…
The aim of the pilot trial is to: 1. evaluate the potential effectiveness and effect size of the online self-management program for patients with Cardiovascular Risk 2. to identify outcome measures most likely to capture potential patient benefit…
In this RCT we investigate the effects of two school-based physical activity interventions (aerobic exercises versus coordinative exercises) in primary school children on executive functions and academic achievement. We hypothesize that both aerobic…
1. Gatekeeper training is effective in enhancing relevant skills 2. Gatekeeper training will diminish rates of (attempted) suicides at regional level 3. The intervention is cost-effective relative to routine medical care