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Effect van lage dosis radiotherapie op pijn bij milde heupartrose

Subjectieve en objectieve evaluatie van het therapeutische effect van laag-gedoseerde radiotherapie op de pijn en functiebeperking ten gevolge van milde artrose van de heup

RAR-CLA and cognition

Daily supplementation of 3.5g RAR-CLA will slow down cognitive decline as compared to placebo

Clinical trial of dabigatran on airway inflammation and coagulation in severe asthma.

We hypothesize that in patients with severe corticosteroid dependent asthma Dabigatran etexilate will: 1. Reduce airway inflammation; 2. Improve asthma control and pulmonary function; 3. Reduce hypercoagulability in the airways.

Fluoxetine and the developing brain.

Administration of fluoxetine during late brain development (adolescence), but not in adulthood, will result in abnormal outgrowth of the 5-HT system. This long-lasting disturbance of the 5-HT system may be visualized using MRI techniques and can…

Effect of a new synbiotic mixture of short chain galacto-oligosaccharides, long chain fructo-oligosaccharides and Bifidobacterium strain on the gut microbiota of caesarean delivered infants.

The study will investigate the effect of a synbiotic test product compared to a control product on the composition and metabolic activity of the gut microbiota of C-section delivered infants.

Assessment of Perinatal Outcome by uSe of Tocolysis in Early Labour: Nifedipine versus placebo in the treatment of preterm premature rupture of membranes.

The aim of the study is to assess whether in women with early PPROM tocolytics improve perinatal outcome.

Dyspepsia - Amitriptyline.

N/A

The effect of intrathecal methylprednisolone on features of central sensitization in patients with Chronic Complex Regional Pain Syndrome Type 1.

Intrathecal methylprednisolone reduce the features of central sensitization in patients with complex regional pain syndrome type 1 having symptoms longer than 6 months and shorter than 6 years.

Melatonin for children with idiopathic chronic sleep onset insomnia, with or without attention deficit hyperkinesia disorder - A dosefinding trial.
A randomised placebo-controlled double-blind parallel group trial.

Chronic sleep disorders are associated with dysfunctioning during the day. Circadian rhythm disorders are a frequently occurring cause of chronic sleep disorders. The time at which the endogenous melatonin production starts to rise plays a key-role…

Dexamethason for the treatment of exacerbations in multiple sclerosis.

In this double-blind randomized controlled trial, we would like to show that a five-day treatment course with 16mg/day oral dexamethason is effective in inducing recovery from an exacerbation of MS.

Exploration of implicit biases in adults who are current cocaine users

1. A decrease in cocaine use over a three month period in participants who receive AAT training as opposed to VPT training. 2. A change in symptoms involving craving, the urge to use, withdrawals well as stated readiness to change in participants…

Comparison of melatonin, temazepam and placebo for the treatment of sleep problems in hospitalized older patients.

Acutely hospitalized older patients frequently suffer from inadequate sleep. Insufficient sleep can lead to patient distress and delayed recovery from acute illness or a surgical procedure. Currently, no evidence-based treatments exist for sleeping…

STOP PAIN

The primary objective of the study ”STOP PAIN” is to compare the effect on migraine attack frequency of transcatheter device closure of atrial shunting with a non-closure group in migraine patients suffering severe migraine with aura.

Sleep position related to hospital length of stay in admitted COVID-19 patients

Predominantly sleeping in the non-supine position could improve oxygenation and thereby shorten the disease course in admitted COVID-19 patients.

Delirium treatment at the surgical ward (DELTa S)
Treatment of delirium: rivastigmine or haloperidol as primary treatment for delirium in elderly patients with a fractured hip.
A randomized placebo-controlled study.

Rivastigmine is as effective in the treatment of delirium as Haloperidol.

Irritable Bowel Syndrome - Budesonide.

N/A

Clinical study to evaluate the safety and efficacy of recMAGE-A3 in patients from which the bladder is removed due to muscle invasive bladder cancer.

The disease free survival will be prolonged in MAGE-A3 positive patients treated with recMAGE-A3.

The effects of propranolol on fear of wisdom tooth removal: A randomized, placebo-controlled, double-blind, parallel design trial

We hypothesize that subjects taking propranolol (1h preoperative and directly postoperative) will report: 1. lower levels of state anxiety 2. lower levels of dental trait anxiety 3. lower levels of aversive traumatic memory 4. lower levels of…

Metabolic effects of Diabecinn (oral cinnamon extract) in diabetes type 2, a placebo-controlled randomized clinical trial.

The main objective of this randomized, placebo-controlled trial is to determine the effects of cinnamon extract on HbA1c and lipid profiles in type 2 diabetic patients.

Train away your gambling problems: online cognitive bias training

Hypothesis 1: Participants who receive either of two CBM interventions will reduce their gambling more than participants completing the placebo intervention immediately after the re-training (post-intervention assessment) and by the 3-and 6-month…