329 resultaten
We hypothesis that collagen supplementation augments the benefits of jumping exercise for bone metabolism.
This is a FIH study for M528101. We expect that the compound is safe and tolerable.
The purpose of this study is to investigate how safe the new compound KCP506 is and how well it is tolerated when it is administered to healthy volunteers. It will also be investigated how quickly and to what extent KCP506 is absorbed and eliminated…
We hypothesize that treatment with Sustained Release Calcium Butyrate (SRCaBu) will ameliorate: 1) the intestinal microbiome, intestinal barrier function and immune tolerance: 2) lower systemic inflammation of OA of the hand.
Rationale: Loss of smell (anosmia) is common in COVID-19 infections. Most patients regain normal smell within 4 weeks, but in 6-8% the smell does not fully recovery. These persistent smell disorders greatly influence daily life. It is thought that…
As the pain quality item “unpleasantness” delineates EB pain, we hypothesize the modulation of affective pain processing in the brain by way of intervention with Transvamix (a CBM comprising THC and CBD) - objectified by functional magnetic…
We hypothesise that relapse of alcohol use will be reduced after two-weeks when participants participate in a AAT during an inpatient alcohol treatment compared to treatment as usual with a placebo AAT (sham training). We also assume that the effect…
Riluzole treatment will reduce psychotic and cognitive symptoms
Based on previous studies, we will expect that ambroxol improves neurological manifestations in patients with GD3.
The goal of this trial is to investigate whether (and at which dose or ratio) CBD has a modulating effect on the psychotropic effects of THC by comparing the effects of THC to the combination of THC with CBD in a range of ratios. Simultaneously,…
We hypothesize that PHA-022121 will be more effective in both the treatment and prophylaxis of acute angioedema attacks in patients with acquired C1-inhibitor deficiency when compared to placebo.
Onderzoeken of drie weken lang CBD spanningsklachten kan verminderen bij hersentumorpatiënten in de stabiele fase kan verminderen, en zo kwaliteit van leven kan verbeteren. Depressieve klachten, slaap/vermoeidheid en algehele kwaliteit van leven…
To reduce fatigue symptoms with the use of a bovine lactoferrin supplement in patients suffering from Long COVID.
The primary objective is to investigate the effectiveness of a personalized 2-year multidomain lifestyle intervention on cognitive performance in older adults at risk of cognitive decline.
To evaluate the safety and tolerability of AP30663 in healthy males at doses up to 12mg/kg
Part 1 Single Ascending Dose (SAD) - To evaluate the safety and tolerability of a single oral dose of prodrug, ABX-002, in healthy adult subjects Part 2 Multiple Ascending Dose (MAD) -To evaluate the safety and tolerability of once daily oral…
Our hypothesis is that the efficacy of FMT in patients with active UC can be increased by: 1. Pretreatment with budesonide in patients with active UC, which may reduce inflammation prior to infusion of the donor feces solution. This reduced…
To investigate the safety, tolerability and pharmacokinetics after multiple daily doses of YTX-7739
A direct patient feedback system can lead to earlier detection of pain and a more timely treatment resulting in improved patient reported outcomes on postoperative pain.
We hypothesize that treatment with Tapentadol will reduce the development of chronic postoperative pain by enhancing or maintaining CPM responses and possibly reducing central sensitization. We hypothesize that a 4-week treatment with Tapentadol…