333 resultaten
To investigate whether CardiOMEMS PA monitoring improves quality of life, reduces HF hospitalizations and is cost-effective in patient with chronic heart failure in the Netherloands
Albendazole could be a novel therapeutic agent for anti-TNF alpha combination therapy in patients with Crohn's disease
After a runic phase of 2 weeks, we will study whether cotreatment of oral E hallii once daily given for 2 weeks on top of stable metformin dosage improves (postprandial) glycemic control in DM2 subjects compared to once daily glycerol placebo with…
This study aims to comprehensively compare the effectiveness and costs of perioperative topical oestriol for postmenopausal women undergoing POP surgery. In this trial, the perioperative use of oestriol is considered superior to placebo which would…
the present study investigates whether Circadian adjusted LED-based (biodynamic) lighting improve cognitive functions, circadian rhytm, behavioral problems (apathy and agitation), Quality of life and mood (depression) in patiënts with moderate- to…
Evaluation of the safety and tolerability of AP3066 in healthy males
adults. We hypothesize that test product NL-01, which is an extract from food crops enriched for IMPP-1, a compound that supports innate immune function, increases resistance to acute respiratory tract infections (ARTI) in the winter season
To investigate the effects of moderate IH exposure for 7 consecutive days on wholebody and tissue-specific insulin sensitivity, substrate metabolism, adipose tissue and skeletal muscle mitochondrial function/content and PO2 in obese insulin…
We hypothesize that the beneficial effetc of Reslizuamb in patients with severe eosinophilic asthma is primarily explained by improvement in small airways function and associated air trapping
The primary aim of this project is to further elucidate the (neural) mechanisms of ketamine, which may underlie its (rapid) antidepressant response.
Sodium phenylbutyrate administration in patients with T2D would improve whole body insulin sensitivity.
Effectiveness of Moving Stories, a game-based school program aimed at depression literacy and stigma
Our first hypothesis is that adolescents who’ve participated in the Moving Stories program will have better mental health literacy and fewer stigmas regarding depression than adolescents who have not participated, both at posttest and at three- and…
Ghrelin administration in comatose patients after cardiac arrest is safe, causes no serious adverse events relatable to ghrelin use and it improves functional recovery in these patients.
It is hypothesized that this personally tailored physical activity program (I’M FINE intervention) will be more effective in improving physical fitness and enhance daily activity in individuals with slowly progressive neuromuscular diseases (NMD)…
Saphenus blok reduceerd opname duur na epifysiodese van de knie - een triple blind superiority trial
We hypothesize that a single shot saphenous nerve block in combination with general anesthesia would be superior to general anesthesia alone regarding opiod consumption. pain scores. recovery and length of stay in adolecent patients undergoing…
What is the influence of protective gear on the performance of basic life support (BLS) by KNRM lifeboat crewmembers during a manikin simulation training
Compared to placebo treatment with low dose amitriptyline or mirtazapine during 16 weeks will improve subjective insomnia in insomnia disorder patients in general practice.
We hypothesize that TRH effectively antagonize opioid-induced respiratory depression
Respiratory Syncytial Virus (RSV) is still the leading cause of hospitalization of children under 5 years of age. Currently, there is no effective treatment licensed for an ongoing RSV infection. Therefore, Intravacc develops a live-attenuated…
We hypothesize that UDCA on top of ezetimibe leads to an increased cholesterol excretion via the feces by stimulating ABCG5/8 and preventing absorption of cholesterol due to blocking NPC1L1 and therefore promoting elimination of cholesterol from the…