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It is hypothesize that -performance on a cognitive test battery (CANTAB) will be negatively associated with brain glutamate concentrations in adults with 22q11DS -Cognitive functioning will improve after riluzole administration compared to placebo.
The aim of this research project is to investigate cannabidiol as a new medicine to target the cannabinoid system in the reduction of anxiety disorder symptoms. The research question is whether cannabidiol, as an augmentation strategy of exposure…
We aim to assess the effects of tyrosine supplementation on prefrontal brain activation, as measured by a combination of fNIRS and EEG, during response inhibition and working-memory performance in older adults. We will also assess whether…
Primary hypotheses The primary hypothesis of the present study is that included patients who receive continuous or intermittent oxygen and bilevel positive pressure ventilation during fixed work rate treadmill exercise tests have shorter recovery…
Bezafibrate will significantly reduce post-prandial non-HDL cholesterol in patients with Familial Dysbetalipoproteinemia compared to placebo.
VR-based postural feedback training combined with non-invasive cerebellar tDCS is more effective as compared to the same balance training program with sham-stimulation in improving postural balance control parameters and standing balance performance…
The aim of the study is to compare the efficacy of pneumodilatation with 'sham'-treatment (placebo intervention). It is hypothesized that pneumodilatation will resolve dysphagia faster than sham dilatation.
The primary aim of this study is to determine whether administration of the active substance (two 40 mg propranolol capsules one hour prior to dental extraction, followed by one 40 mg capsule directly postoperatively) results in a significantly…
It is hypothesized that: -there will be a subgroup of patients with first episode psychosis with reduced Muscarinic M1 receptor binding. -The patients with reduced M1 receptor binding will perform significanlty worse on a cognitive test battery (…
Intracervical installation of terlipressin reduces the incidence and severity of gas embolsim and the amount of intravasation during hysteroscopic surgery
To evaluate whether a dietary advice of green vegetables, beef and whole dairy products during six months including standard supportive care can decrease the TSH-level compared to standard supportive care alone in children aged 1-18 years with…
primary: 1.CCT reduces rumination in depressed patients. secondary: 2. The effects of CCT on working memory effect generalize to other Working memory tasks (neutral and emotional). 3. CCT has an effects on the mood of depressed patients.
We hypothesize that: 1) Patients receiving an ice-lolly or chewing gum directly postoperative will have lower pain intensity scores in the 24 hours following surgery compared to no non-pharmacological treatment. 2) Patients receiving an ice-lolly or…
This study investigates whether light therapy is an effective treatment for depression during pregnancy. Secondly, it investigates the late effects of bright light therapy on quality of sleep, endocrine function during pregnancy and birth outcome.…
Bezafibrate alleviates itch complaints in patients with cholestatic liver disease.
-Children who receive the more prolonged working memory training with personalized coaching have less behavioural problems (VISK, AVL, BRIEF) after the training compared to children who receive the more prolonged working memory training without…
The use of atorvastatin in persons at high risk of RA is associated with a reduction in de development of arthritis
Is there a diiference in antidepressant efficacy between ECT and a combination of ECT and nortriptyline? Does combination therapy with ECT and nortriptyline result in a faster antidepressant response compared with ECT monotherapy? Does combination…
Children aged 4 to 6 years in the intervention group who have received the GigaGaaf! intervention have a different oral health than children aged 4 to 6 years from the control group who have received care as usual. Parents of the children aged 4 to…