1055 resultaten
Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that alters cortical excitability. A recent study in anaesthetized cats showed that tDCS also facilitates subcortical neurons. Here, we hypothesize that…
Primary objective: - To evaluate the safety and tolerability of NT-0167 in healthy volunteers Secondary: - To evaluate the pharmacokinetic (PK) profile of NT-0167 in healthy volunteers after the administration of single ascending (SAD) and multiple…
Daily supplementation of 3.5g RAR-CLA will slow down cognitive decline as compared to placebo
First, it will be investigated which is the best diagnostic tool for imbalance in CP. Second, it will be determined whether balance training can promote balance control in CP, and whether the improvements will be maintained after a follow-up period…
It is hypothesize that -performance on a cognitive test battery (CANTAB) will be negatively associated with brain glutamate concentrations in adults with 22q11DS -Cognitive functioning will improve after riluzole administration compared to placebo.
The study aims to assess the efficacy (in terms of growth response over the years of treatment, including final height) and safety of a treatment regimen consisting of: 1. Authentic biosynthetic growth hormone (GH) in a dosage of 4 IU/m2/day between…
Red pepper might prevent reduction of energy expenditure and elevation of hunger as a result of energy intake restriction.
VR turned out to be promising as adjunct non-pharmacological intervention during wound dressing changes. Because the evidence for VR as pain relief is limited, more high-quality studies are needed to investigate the effect of VR on procedural pain.…
We hypothesize that in patients with severe corticosteroid dependent asthma Dabigatran etexilate will: 1. Reduce airway inflammation; 2. Improve asthma control and pulmonary function; 3. Reduce hypercoagulability in the airways.
1. High-resistance strength training leads to greater improvements in muscle strength (primary outcome), pain, activity limitations, self-reported knee-instability, falls and fractures, markers for inflammation and depression and anxiety (secondary…
CI-AKI preventive hydration is not needed in patients with a creatinine clearence between 30-60 ml/min undergoing intravenous contrast media-enhanced CT.
We expect that there will be a difference in energy intake after 2 weeks of supplementation of a bar with 10g added fibre out of chirory root pulp (CRP) compared to 2 weeks of supplementation of a control bar. We hypothesize that the energy intake…
To investigate whether microbial transplantation from either allogenic (healthy) or autologous (own) donor, administered through a small intestinal tube, has beneficial effects on immune status, betacell function (Cpeptide secretion upon a mixed…
We hypothesis that collagen supplementation augments the benefits of jumping exercise for bone metabolism.
The mother baby intervention positively affects the quality of the mother-child interaction, particularly the mother’s sensitivity towards her child and the child’s responsiveness and involvement, and (2) The intervention positively affects the…
Hypothyroidism is a chronical disease with a bad influence on quality of life in this patients. Some researchers mean that self control in treatment and medication is a potential good development that can improve medical condition, make patients…
We hypothesize that administration of intranasal insulin: 1. Inhibits endogenous glucose production, indepently of systemic insulin; 2. Increases the insulin concentration in the cerebrospinal fluid (CSF).
We hypothesize that liraglutide treatment, initiated before cardiac surgery, is effective in lowering the number of patients needing perioperative insulin adjustments and reducing the total amount of insulin needed in the perioperative period when…
• clonazepam administration has acute beneficial effects compared to placebo on neurocognitive tests. • multiple-doses clonazepam has beneficial effects compared to placebo on behaviour and cognitive function in ARID1B patients as measured by the…
1. Show that Growing Up Milk, as part of a healthy diet, can fill nutritional gaps, with special attention to the iron and Vitamin D levels, in young children is more efficient than a healthy diet with cow's milk; 2. Increase of the serum iron…