63 resultaten
The main clinical challenge remains to identify patients who may benefit from aggressive local treatment (stereotactic radiotherapy, SBRT) of soft tissue oligometastases: for which patients can systemic treatment be postponed? Patients who are…
Mortality will be lower in patients who do not smoke during treatment of non-small cell lung carcinoma with PD-L1-inhibitors compared to patients who smoke during their treatment with PD-L1-inhibitors.
SARS-CoV-2 is present in the cerebrospinal fluid of COVID-19 patients with acute respiratory failure
The relative risk of developing macular edema in diabetics after cataract surgery is enhanced.
Augmentation of the maxilla with calvarial bone has a lower complication rate than iliac crest bone.
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To evaluate the effects of thoracic epidural anaesthesia (TEA) with general anaesthesia on mean systemic filling pressures, arterial- and venous resistance and cardiac output. To assess the hemodynamic effects of vasopressors and fluid loading under…
a higher protein intake at the end of the first treatment cycle in patients with CRC or NSCLC undergoing first line treatment with chemo-, concurrent chemoradio- or immunotherapy who are receiving two servings of test product daily and who completed…
As EGFR plays a role in pathogenesis of both pulmonary arterial hypertension and systemic sclerosis, EGFR inhibition will lead to beneficial effects in disease course.
The aim of this study is to assess the predictive value of the HowRwe questionnaire in relation to the EUROPEP questionnaire by analyzing scores acquired in Dutch GP practices. We expect that high HowRwe scores are associated with an positive…
We hypothesize that the circulatory and cardiac effects of TEA will be most pronounced during circumstances of increased sympathicotonus, which will be induced by an exercise test on a bicycle.
The primary hypothesis of this study is that Opsys will improve mild incontinence based on urine loss per 24 h measured by 24 h pad weight test (PWT). Primary Objective The primary objective of this study is to test the effectiveness of Opsys in a…
1. It is hypothesized that participation in the Active plus program contributes to an increase in physical activity behaviour among older adults; 2. Additionally receiving physical and social environmental information results in an extra increase…
Chronic allograft nephropathy is the main cause of long-term renal transplant failure. The pathogenesis involves amongst others calcineurin inhibitors. We performed a multicenter randomized trial to study the effects of withdrawal of ciclosporin (…
Nebulizing amoxicillin clavulanic acid is more effective for reaching amoxicillin levels in sputum > MIC90 than amoxicillin clavulanic acid given by oral or intravenous administration.
To develop a dosing nomogram of irinotecan in patients homozygous polymorphic for UGT1A1*28 and/or UGT1A1*93 in order to reduce the incidence of severe irinotecan-associated toxicity, defined as febrile neutropenia in the first 2 cycles (amendment…
The gastric balloons are expected to remain in the stomach for approximately four weeks, after which they burst and are fecally excreted. It is further hypothesised that intragastric balloons can provide a surrogate stomach fill, inducing an…
The RAINBOW study: Rheumatoid Arthritis ImplemeNtation of Biological dose Optimization in real World
We hypothesize that a multifaceted implementation strategy can stimulate the use of tight control and bDMARD dose optimization in clinical practice, measured by decreased bDMARD use and non-inferiority on disease activity at 18 months.
Simvastatin (an HMG-CoA reductase inhibitor) induces apoptosis in vitro and sensitizes the myeloma cell to chemotherapy. This is the first clinical trial to test if in vivo there is the same sensitization in relapse or refractory multiple myeloma.
Does lipid accumulation in skeletal muscle and the heart effect mitochondrial function in relation to insulin resistance?