427 resultaten
We hypothesize that PARP inhibitors can potentiate radiation-induced tumor cell death in patients treated with PRRT. To determine the maximin tolerated dose (MTD) of this combination, a phase 1 dose-escalation study is needed.
Two doses of the Coronavirus virus-like particle subunit vaccine ABNCoV2 in SARS-CoV-2-naïve healthy adults is safe and well tolerated.
We hypothesize that the HINTS+ test is more reliable than early MRI imaging in patients with acute onset continuous dizziness. As a result it is hypothesized that HINTS+ clinical examination leads to lower costs and an improvement in Quality of Life…
the quality of consultation can be improved
Het primaire doel van het onderzoek is om te onderzoeken of veranderingen over de tijd in monitorende metingen van cognitie en gedrag gerelateerd zijn aan functionele uitkomsten in pediatrische oncologie groepen. Overige doelen zijn het onderzoeken…
Semi-structured interview study to get insight in parents’ experiences of daily use of a stander in young children with cerebral palsy to prevent hip dislocation. In addition, data will be used to identify barriers and facilitators to improve future…
Determination of preoperative cell-free DNA and circulating tumor cells alone or in combination with each other in peripheral blood of patients with colorectal liver metastases can discriminate between patients who have a recurrence of metastatic…
The hypothesis is that a single course of 12Gy preoperative radiotherapy may lead to sufficient fibrosis in a small (4cm) targeted area of pancreatic tissue where the anastomosis with either the jejunum will be created, thereby reducing the risk of…
patients with a history of drug allergies carry more HLA risk alleles than patients without drug allergies.
The goal of EEG4STROKE is to test a device that enables paramedics to accurately diagnose patients with suspected stroke on site (in the ambulance or living room of the patient). EEG4STROKE will integrate hardware and software to triage stroke…
Diaphragm thickness is constant throughout the zone of apposition in craniotomy-caudal direction
Het hoofddoel van dit onderzoek is om het effect van een chirurgische correctie van een spits-varus voet ten opzichte van conservatieve behandeling op het behalen van persoonlijke doelen te evalueren. Daarnaast wordt het effect van een chirurgische…
We hypothesize that the MACE and mortality rates will be very low, due to mild or absent coronary disease on the CCTA and the short follow-up duration.
It is hypothesized that CATs and PROMIS short-forms have higher measurement precision and smaller measurement error (better detectable change) as compared to currently used PROMs.
The Trammpolin® medial meniscus prosthesis is intended to restore the function of the natural meniscus to provide unicompartmental pain relief in the meniscus-deficient knee and redistributes the loads transmitted across the knee joint. The ability…
It is hypothesized that measurement of CO, SV and LVEF with the Lumify/DIA system corresponds with CO, SV and LVEF measurements with conventional non-automated echocardiography.
The aim of the present study is: can a single case observation of two distinct phases during systole (laminar and turbulent) be confirmed in other patients with aorta stenosis?
Data extraction with CDC to study the effectiveness of Novasure endometrial ablation is reliable compared to manual EHR data extraction
1/2. Postoperative infections are a risk factor that negatively interferes with physical recovery 1 year after cardiac surgery. It is expected that propensity scoring techniques will provide a more accurate (“unbiased”) estimate of the effect of the…
The clinical efficacy of CFTR modulating drugs is limited, some patients respond, while others do not or have side effects. The inter-individual variability (IIV) in the PK seems large, and therefore we hypothesize that we might be over- or…