100 resultaten
In this explorative study we will examine the impact of daily ischemic preconditioning on brachial artery endothelial function (measured as FMD%, before and after IRI) during 7 days in the non-shunt arm and lower limb in patients with end-stage…
- Hypothesis#1 efficacy We hypothesize that a quick onset, and a predictable dose-response, good adjustability of analgesia can be achieved with inhaled ketamine. Hypothesis#2 safety Inhalation of nebulized ketamine might lead to a fast onset of…
Our hypothesis is that high-dose, pulsatile sorafenib may exhibit improved efficacy with an acceptable toxicity profile compared to standard continuous dosing. AUC escalation cohorts are used instead of the conventional dose escalation cohorts,…
We expect that mp-MRI, molecular urine test and Prostate Cancer Risk Calculator may be of additional value in differentiating between significant and insignificant cancers in men with an elevated PSA in the primairy diagnosis. If so, it will result…
The primary objective of this study is to explore the correlation between invasive and non-invasive haemodynamic variables and monitor the effect of treatment during admission for acute decompensated heart failure. In particular to investigate…
First objective: To study the influence of mucositis on the absorption of sublingually delivered fentanyl (Abstral ®) in head and neck cancer patients treated with chemoradiotherapy. Secondary objectives: to study the influence of xerostomia on the…
we hypothesize that paediatric patients with per-operative rhinovirus positive Polymerase Chain Reaction (PCR) testing have a longer paediatric intensive care unit (PICU) admission , compared to children who test negative.
Metabolic disturbances associated with critical illness may disturb secretion of melatonin, the most important factor for circadian timekeeping. This disturbance may in turn hamper distribution and high quality sleep, with potentially detrimental…
First, non-invasive diagnostic tools can optimize the diagnostic strategy, in order to minimize the number of invasive diagnostic procedures. Second, invasive imaging of the pulmonary artery can further differentiate the mechanisms involved in PH…
The aim of the study is to develop a screening tool to identify young children at risk of posttraumatic stress disorder following an accident.
Use of this walk-bike in daily life extends the range and everyday mobility of IPF patients, thereby decreases the level of dependency and social isolation, factors that are associated with quality of life. If, with this low-cost intervention, daily…
Rationale: Hypertension is the most common cardiovascular condition responsible for the development and maintenance of atrial fibrillation (AF). Treating drug-resistant hypertension with renal denervation has been reported to control blood pressure…
The ABSORB DM registry is designed to perform follow-up of all DM patients who have undergone ABSORB family placement. This international database will allow follow-up of all adverse events related to the product and/or the procedure. Specifically…
Objectives: 1) To describe the incidence and severity of cognitive impairments in patients with glioma and meningiomas before, and 3 and 12 months after surgical treatment. 2) To develop models based on presurgical sociodemographic, clinical,…
The hypothesis is that a graded physical exercise program in which strength and endurance are trained have a positive effect on fatigue after stroke measured with the CIS-f (Checklist Individual Strength subscale fatigue) or FSS-7 (Fatigue Severity…
Diabetes Mellitus (DM) patients with angiographically intermediate coronary lesions remain at risk for future MACE events, including those patients with fractional flow reserve (FFR) negative lesions. Use of FFR measurements combined with Optimal…
In the process of developing a serious game for testing patients’ level of myocontrol a part of the test needs to be validated. In a previous trial we found differences between several tests that need further inspection. The current study focusses…
The fall risk application of Gociety® is a valid method to identify fall risk profiles among elderly.