189 resultaten
3D information from CT and MRI can be used as gold standard on the quantity to be computed from a mammographic projection image.
The standard SLNB technique (patent blue dye and radioisotope; or radioisotope alone) used in breast cancer patients has several drawbacks. The use of radioisotope exposes patients and healthcare workers to radiation, is heavily controlled by…
1. To estimate the percentage of quantitative RT-PCR negative pediatric CML patients in which Imatinib discontinuation result in sustained complete molecular remission; 2. To determine whether restarting of Imatinib or another tyrosine kinase…
We hypothesize that discriminable responses between oral exposure to caloric and non-caloric stimuli are observed in the following areas: the anterior cingulate cortex, the striatum, the amygdala and areas related to brain reward circuitry (e.g. VTA…
The primary study design was a phase III study with randomization with the hypothesis that bortezomib+dexamethasone has a better outcome than only dexamthe. However due to slow inclusion the expectation was that the primary endpoint could not be…
There is increasing evidence that women with hypertension or preeclampsia during pregnancy are at increased of cardiovascular diseases later in life compared to women with normotensive pregnancies. As suggested by previous studies, placenta…
Fentanyl is highly lipophilic. Localizations with a thicker fatlayer absorp more fentanyl than localizations with a thinner fatlayer. When patients stick the patch in different localizations this can lead to different concentrations of fentanyl.…
By comparing protein profiles of dysplastic vs non-dysplastic Barrett epithelium, a novel biomarker for prediction of early neoplasia may be identified.
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The number of people undergoing total hip or total knee surgery is growing. The majority of these patients has a favorable outcome with respect to pain, function and quality of life. In a small group of patients however the results are disappointing…
The annual incidence of castration-resistant prostate cander (CRPC) in the Netherlands is estimated at 2868 patients. After development of CRPC, survival with best supportive care is not expected to exceed 12 months. Fortunately, several new…
Influenza-like-illness (ILI) is not only caused by an influenza virus infection, but also by other pathogens, both viral and bacterial. In this study nose and throat swab samples will be taken during ILI episodes to identify pathogens causing ILI in…
Usage of SDD or SOD has been shown to reduce the incidence of ventilator associated pneumonia (VAP) and to improve patient survival. SDD and SOD were shown not to increase resistance of bacteria colonizing the digestive tract. It can not be excluded…
We expect we can estimate VO2max accurately using the relation between heart rate and level of activity measured outside the laboratory setting in comparison to VO2max determined during a maximal bicycle ergometer test.
B cells play a role in multiple sclerosis, not only by production of autoantibodies but also by presentation of (auto)antigens to autoreactive T cells.
To quantify health risks in relation to preventive actions and consequences of illness related to travel in immigrant and non-immigrant immunocompromised travellers treated with MTX and/or anti-TNF-alpha monoclonals, imuran or rituximab.
MBL deficiency might give rise to a higher chance of the occurence of febrile neutropenia.
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To determine the current views of medical residents and educators on current assessment methods of care management competencies and potential assessment tools that can be used to improve care management evaluation. PHASE 3: 1. Literature review to…