189 resultaten
The primary aim of this study is to investigate the process of implementation of the Dutch multidisciplinary guideline for obese children according to the implementation process of Grol and Wensing. The secondary aim is to investigate whether the…
Anorexia Nervosa (AN) is a serious condition and forms a major public health problem. The disorder affects biological, psychological as well as social functioning, affects mainly young people, tends to take on a chronic course in a considerable…
Nilotinib plus PegIFN will increase depth of response in CML patients who have stable responses above 0.01%.
The aim of the study is to determine whether cardiac output measurements obtained using APCO are comparable with those obtained using transpulmonary (advanced FloTrac software) and intermitted bolus thermodilution cardiac output in critical ill…
For patients with severe symptomatic aortic valve disease, aortic valve replacement surgery is the treatment of choice. Two options exist: Mechanical and bioprosthetic aortic valve. The decision which valve type to choose is difficult, since in most…
The quality of human milk shows an association with the women's diet and lifestyle.
We aim to compare IGF-I bioactivity levels between patients with favorable and unfavorable functional outcome 3 months after acute ischemic stroke. Furthermore, we will compare the IGF-I bioactivity levels between patients with and without…
We will test the following hypothesis: implementation of hospital-wide CVC insertion and maintenance bundles on the guidance of the Pronovost-model promotes adherence to its use and reduces the number of CA-BSIs.
Improved and earlier delineation of the course of the ureter by intraoperative fluorescence imaging.
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Tamoxifen pharmacokinetics may be influenced by circadian rhythm. Endoxifen exposure may differ between morning administration of tamoxifen and administration in the evening. Amendment (1-apr-2013): Tamoxifen pharmacokinetics may be influenced by…
Peroperative fluorescence of the bile ducts will improve visibility and result in early identification of the common bile duct and cystic duct during laparoscopic cholecystectomy.
[11C]Erlotinib pharmacokinetics may be comparable between non-small cell lung cancer patients with and without erlotinib therapy.
This study aims to investigate the value and feasibility of a disposable TEE to monitor both fluid responsiveness and global contractile function of both left and right ventricles in high risk surgical patients, including both intraoperative…
Two hypotheses will be tested. First, we expect differential susceptibility, which means that children in the intervention condition who carry one or more susceptibility genes (i.e., carrying a MAOA low activity (short) allele; DAT 10-repeat allele…
Vaccination against pneumococcal bacteria results in eradication of nasopharyngeal colonization by pneumococcal serotypes present in the pneumococcal vaccine in vaccinated children and their parents but serotypes not included in the vaccine fill in…
1. The in vitro immunological reactivity is higher in adolescence compared to adjacent age categories which leads to a higher risk of rejection of the transplanted kidney; 2. More naïve T-cells are present in the circulation in adolescence compared…
To prospectively study the incidence of polyps and CRC in first degree relatives of patients with serrated polyposis syndrome.
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