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Focusing on disease-modifying rather than etiologic mechanisms may accelerate the development of novel therapies and complement current research initiatives on causative mechanisms and curative therapies.
Education on guidelines, combined with quality targets within the accreditation procedure improves quality of antibiotic prescribing
Different prevention strategies are used internationally to prevent Early-onset Group B haemolytic streptococcus infection (EOGBS). However, none of the preventive EOGBS strategies in place at present result in the complete prevention of EOGBS,…
An upfront RBCT aiming at low-normal Hb levels will ameliorate anemia-caused tumor hypoxia-related resistance to chemotherapy before the start of chemotherapy and may decrease secondary anemia-induced endogenous release of cytokines like VEGF,…
Home DC-ECV in general population patients with an episode of symptomatic recurrent persistent AF, carried out by ECPs, is feasible, safe and is associated with reduced costs.
There is no difference between CT- and MRI-based Patient specific matched instruments for total knee arthroplasty
The primary objective of this study is to determine whether thrombectomy combined with ischemic postconditioning after PCI leads to a smaller myocardial infarction compared to standard therapy.
The purpose of this research is to acquire a better understanding of the pain experience and the recovery of children between 1.5 and 5 years old who underwent a tonsillectomy/adenotonsillectomy. Primary research question: What is the influence of…
Spinal anesthesia induces several alterations in normal brain processes. Firstly, loss of afferent information increases pain sensitivity. In our previous study on the effects of spinal anesthesia (P11.221) we showed that subjects felt more pain…
Tamoxifen and endoxifen serum concentrations are linearly related to DBS concentration
The primary endpoint is to evaluate the use of Souvenaid in patients with early AD in real world clinical practice by assessing the effect of Souvenaid on patients’ functioning on instrumental activities of daily living (IADL) as perceived by the…
The aim of this phase I study is to assess the extent of intestinal absorption of rivaroxaban and dabigatran etexilate in adult patients with short bowel syndrome requiring long-term TPN.
The aim of the study is the assessment of microcirculatory alterations induced by xenon or sevoflurane anesthesia in patients with compromised left ventricular systolic function.
1. Patients with patent stents will have improved AVP and improved flow in CFV; 2. Patients with stent occlusion will have significantly higher AVPs and lower flow in CFV than patients without stent occlusion; 3. (Pain-free) walking distance will…
The efficacy of transluminal drainage of pancreatic fluid collections may be increased by creation of a larger fistula than currently possible with placement of multiple plastic endoprostheses.
The carotid artery reactivity-test will have independent prognostic value compared to the current, standard prognostic tests (i.e. ankle-brachial-index, walking distance) for patients with peripheral artery disease
Improved understanding of slow conducting anatomical isthmuses in Tetralogy of Fallot and cryoablation of these slow conducting anatomical isthmuses during pulmonary valve replacement might prevent VT re- and occurrence.
Individuals with a single, non-specific symptom are often identified with a genetic variant of unknown significance in the Alpha Galactosidase A gene that is involved in Fabry disease. Assessment of Small fibre neuropathy that is often present in…
Information on the dynamics and shape of the device and how these change over time will improve our understanding about the fixation and/or sealing of the device, which may help in stent selection and in designing stent grafts that are more durable.
One way of providing binaural cues to unilateral CI recipients is to wear an acoustic hearing aid in the contralateral non-implanted ear, known as bimodal hearing. The benefits of bimodal input (e. g. speech perception in noise, localisation,…