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1. Prosthetic valve characteristics (type; location; size resulting in the presence/absence of PPM) are related to functional outcome and quality of life; 2. The incidence/spectrum of prosthetic valve-related complications in adults with CHD differs…
Antipsychotics (haloperidol) can cause acute changes in cardiovascular functions, metobolic parameters and platelet aggregation in elderly patients.
Background: Injury rate and injury severity of elderly cyclists due to self-induced cycle accidents increase with age. Starting at the age of 55 years, injury risk increases with a factor 4 at the age of 75 years. Injury mechanisms such as slippery…
Combination therapy with telaprevir/ ribavirin is as effective as the current standard of care with peginterferon-alfa/ ribavirin for the treatment of acute Hepatitis C in HIV-infected individuals.
Pyridostigmine will activate the parasympathetic cholinergic anti-inflammatory pathway and therefore reduce inflammatory signs and symptoms in patients with complex regional pain syndrome.
Recurrent miscarriages is defined as three or more consecutive miscarriages prior to the 20th week of gestation. Whenever the diagnosis ‘recurrent miscarriages’ is established, an underlying cause may be identified in about 25-50% of cases. A…
Despite good results of primary total knee arthroplasty (TKA) the number of revision total knee arthroplasties (rTKAs) is rising and a further increase is predicted. rTKA is a more complicated surgical procedure compared to primary TKA and leads to…
In chronic pain the processing of sensational and painful stimuli will be disturbed. In patients with effective spinal cord stimulation the processing will normalize.
The hypothesis of this study is that segmental kyphosis can be maintained after removal of the short-segment pedicle-screw instrumentation in biological young patients with traumatic thoracolumbar burst fractures. In these patients in addition to…
Hearing aid fitting will reduce the tinnitus burden in patients with mild hearing loss.
The effect of stepping down asthma therapy in clinically stable children on exercise induced asthma.
We hypothesized that in a subgroup of patients EIBH would improve after the cessation of LABA.
We hypothesize that motivational and behavioral characteristics of eating behavior, in addition to genetic and environmental factors play a major role in the development of obesity. We aim to identify obesity subtypes based on these factors.
In patients with side effects, during VNS, there is: 1. A decrease in lung function parameters; 2. A reduced increase in heart rate; 3. A reduced increase in blood pressure.
The following research questions will be determined: 1. What is the effect of an nutritional intervention compared to usual care in undernourished patients of 65 years in general practice or using home care? 2. What is the cost effectiveness of an…
The hypothesis is that rhGH treatment in children with KS results within 6 weeks in a change of metabolism recognizable as an increase of total energy expenditure (TEE). This change in metabolism can be used as a predictor of growth response in the…
The application of the haemostatic device, ACF-matrix haemostat will reduce blood and fluid loss from the LIMA bed after CABG surgery.
1. To estimate the percentage of quantitative RT-PCR negative pediatric CML patients in which Imatinib discontinuation result in sustained complete molecular remission; 2. To determine whether restarting of Imatinib or another tyrosine kinase…
Presence of postural instability and gait dissorder PIGD (gait disorders, balance impairment, falls, fal-related injuries and FOG) are an important and disabling feature of idiopathic Parkinson’s disease (PD) where the level of functional ability is…
To get insight in the long term results (mortality, morbidity and cardiologic function) of patients with congenital heart disease operated at young age. To compare whether the changes in surgical techniques have resulted in an increase of (…