66 resultaten
The age-specific seroprevalence of a cross-section of the Dutch population for the vaccinations used in the Dutch National Immunisation Programme.
The hypothesis of the present study is to demonstrate that detection of a particular pattern (e.g., persistent vs. non-persistent) of myocardial (alpha)V(beta)3/5 expression by scintigraphy imaging at 3 and 8 weeks after MI can be used to determine…
It is our hypothesis that a combined life style intervention of exercise and weight loss will result in a reduction of pain and improvement of function of the affected hip joint, which will postpone a chirurgical intervention.
Donor-specific antibodies form a significant barrier in transplantation of highly pre-sensitized dialysis patients. Increased waiting time is associated with increased morbidity and mortality among these patients. Thus, there is a need to further…
The EEG profile in responders to methylphenidate will be differ from the EEG profile in non-responders to methylphenidate (i.e. higher total power, increased theta/beta ratio and theta/alpha ratio).
The primary objective of the study is to study the safety of MMR booster vaccination in JIA patients by measuring JIA disease activity and the occurrence of measles, mumps or rubella infection. The next primary objective is to evaluate the efficacy…
According to the current national guidelines, as formulated by the Dutch Society of Cervical Pathology and Colposcopy in 1995, the follow-up in women treated for high grade Cervical Intraepithelial Neoplasia lesions consists of cervical cytological…
The primary goal is to show the capability of monocyte-derived DC after RNA electroporation for multiple antigens to induce an immune response. The secondary objective is to show clinical response.
The primary objective of this trial is to validate the screening potential of NT-proBNP in a population of low to intermediate risk patients, i.e. patients with zero to two cardiac risk factors, scheduled for vascular surgery. The secondary…
There is an increase in concentrations of cytokines IL-1alpha, IL-1RA and IL-8 (as measured using Sebutapes) in the skin of the arm in healthy volunteers after mechanical loading of the skin, compared with an control measurement.
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1. a. Does influenza vaccination in SLE and Wegener patients result in a decreased humoral immune response compared to healthy age-matched controls?; b. Does influenza vaccination in SLE and Wegener patients result in a decreased cellular immune…
This trial aims to demonstrate the superiority of PEG doxorubicin (with 3 months) over capecitabine as first line chemotherapy in patients with metastatic breast cancer.
To determine attendance for CRC screening with guaiac based FOBT (Haemoccult II), immunochemical FOBT (OC-Hemodia Latex) and sigmoidoscopy.
To assess the effect of adalimumab (anti-TNF alpha) and rituximab (anti- B cell) therapy on the safety and efficacy of vaccination with T cell-dependent and T cell-independent primary and recall antigens.
The change of chemotherapeutic temozolomide schedule from conventional to metronomic treatment may overcome temozolomide resistance in patients with recurrent glioma without any major toxicity. Administration of angiogenesis inhibitor bevacizumab…
Treatment Adherence Therapy + Treatment as Usual (TAT+TAU), as compared to TAU-only, has a beneficial effect on treatment adherence, as defined by no-show contacts, the degree of collaboration in managing the illness, help seeking behaviour in…
The hypothesis of this study is that the pubertal delay in transsexual adolescents, induced by treatment with GnRH analogues, will cause a difference in the development of brain structures and brain function between transsexuals and age matched…
Application of sentinel node biopsy (in comparison to or combined with ultrasound guided fine needle aspiration cytology) improves the detection of occult lymph node metastases to a clinically relevant extent.
Probiotics, defined as microbial food supplements that improve intestinal colonization resistance, will decrease incidence and prevalence of gut colonization with CC17 ampicillin-resistant E. faecium (ARE) in hospitalized patients.