58 resultaten
We hypothesize that the underlying mechanisms of the varying response in multiple parameters within an individual can be attributed to variability in the causal path between drug administration, drug tissue distribution, and tissue receptor…
The new interdisciplinary protocol will attract attention to these cases of hand injuries and patients will get a chance of a better coordinated treatment at the early rehabilitation phase. To restore early function of the hand proper instructions…
The hypothesis is that all procedures look different per therapist and parent collaboration and all experiences are different. Nevertheless, there possibly will be similarities in experiences and wishes for the future.
We expect to develop a robust predictive model with which to identify patients who are most likely to benefit from STN-DBS, thereby optimizing the screening procedure for DBS.
To determine the influence of optical quality on perimetry for phakic and pseudophakic healthy and glaucoma patients. To determine the influence of CLE on perimetry and optical quality for PAC patients.
We hypothesize that 1) fasting duration may affect the central serotonin and dopamine systems, either centrally or indirectly through effects on peripheral input to the central nervous system, and 2) the effect of fasting may be changed in obesity.
The aims of the study are: To investigate the short-term effectiveness of antecedent and consequent behavioral parent training techniques for parents of children (four to twelve years old) with attention-deficit/hyperactivity disorder (ADHD) on…
Survivors of sepsis are at high risk for the development of chronic kidney disease (CKD), cardiovascular events and mortality. Mitochondrial dysfunction, which mainly results from increased generation of free radicals, plays a key role in the…
The aim of this study is to show whether TDM leads to a lower proportion of patients with drug levels below the predefined TDM targets after 12 weeks
With implementation of the AWR and APWR by the ED triage nurse we expect a reduction in the total number of radiographs requested, without missing any clinical relevant fractures. We also expect a reduction in overall waiting times at the ED and…
Victims of IPV, living in an unsafe and unhealthy situation, are faced with a broad range of physical and emotional symptoms. Standard and easy-accessible care to facilitate change into a safer situation is lacking. The project aims to launch an…
Repetitive ePIPAC-OX as a palliative monotherapy is a feasible, safe, tolerable, and potentially effective treatment for isolated unresectable colorectal peritioneal metastases, with low and predictable costs and a low systemic uptake of oxaliplatin…
Providing vascular surgical patients and vascular surgeons with decision support tools will improve the level of shared decision-making during consultation, increase disease-specific knowledge and quality of life and decrease decisional conflict.
In the Netherlands, 90% of the patients with gout are managed by general practitioners but most research has been done in secondary care. In primary care there are questions on the clinical relevance of long-term uric acid lowering treatment of gout…
to assess the detection rate and accuracy of 18 F-FDHT PET/CT and compare to current standard restaging modalities.
Primary hypotheses: 1a. Striatal [18F]DOPA influx (Ki) values in non-psychotic individuals with ASD are positively related to the total score on the UCLA Loneliness Scale (as an approximate measure of social defeat). 1b. Non-psychotic individuals…
Patients undergoing superior capsule reconstructions (SCR) for superior shoulder instability will experience less pain (decrease of at least 2 points) and improved function.
A decline of intra-tumoral concentrations over time could be the first sign of the development of drug resistance by the tumor. In this exploratory study we will investigate the relationship between plasma and intra-tumoral paclitaxel concentrations…