49 resultaten
COMT and/or PRODH polymorphisms are debt to cognitive deterioration in velocardiofacial syndrome.
The present study aims to get more insight into the various aspects that govern adherence to the oral anticancer drug erlotinib in daily practice.
Our primary objective is to determine whether testing for molecular markers, i.e. hrHPV, CADM1/MAL methylation and combinations thereof, yields a higher sensitivity and specificity for the detection of CIN2/3 or cancer after treatment in comparison…
A near-infrared fluorescence camera and a peritumoral injection of indocyanine green may be used for detection of lymph nodes during esophageal resections without affecting the normal operative procedure.
After non-myeloablative allogeneic SCT the hematopoiesis is from donor origin (100% donor chimerisme) in almost all cases. The origin of DCs is important in presenting minor antigens to donor T-cells. Autologous or host DCs are capable to directly…
The extrahepatic bile ducts may be visualized during cholecystectomy using a near-infrared fluorescence camera and an injection of indocyanine green into the gallbladder.
The aim of this study is to examine the dynamics of escape mutations and reversions in relation to the Human Leukocyte antigen (HLA) type of the HIV-1 donor and the HLA type of the HIV-1 recipient. In addition, the HIV-1 sequence dynamics in…
The TRIUMPH clinical cohort aims to identify and validate potentially clinically important biomarkers. These novel biomarkers need to be implemented in the clinical management of acute (and chronic) heart failure patients to monitor disease…
Radiotherapy involving a high biological dose with a limited treatment volume achieves a local tumor control rate of at least 90% in patients with metastatic cancer to the lung.
Complex symptoms such as suboccipital pain, irradiating into the occiput, vertex and sometimes as far as the eyes may originate from the atlantoaxial joint. Intra-articular injections of corticosteroids were found to be more effective in patients…
Improved detection of tumor.
1. Vascular inflammation becomes activated several days to weeks before an acute coronary syndrome; 2. Biomarkers of vascular inflammation, distorted lipid metabolism, endothelial dysfunction, diminished endothelial regenerative capacity,…
1. Null hypothesis (H0): PFS at 1 year after start lenalidomide maintenance = 59%; 2. Alternative hypothesis (H1): PFS at 1 year after start lenalidomide maintenance = 75%.
We postulate that the development of asthma in preschool children can be captured during the first 2 years of life by a minimally invasive ‘fingerprint’.
Based on the type of cognitive impairments frequently observed in children with frontal lobe epilepsy, functional networks in the frontal and/or temporal lobe are expected to be disrupted. Therefore we expect neuronal reorganisation especially in…
We hypothesize that that single neuron recordings from depth micro-electrodes in candidates for epilepsy surgery can be used to reconstruct brain networks, and to determine the impact of epilepsy on these networks. This setup will allow us to…
To study whether dynamic MRI can predict treatment response and long term outcome in patients with Crohn’s disease.
Sentinel lymph node detection with fluorescent probes.
We will study which factors differ between the responders to oxygen therapy and the non-responders. Factors that will be studied are for instance patient characteristics, headache characterisics, comorbidities and intoxications.
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