35 resultaten
The age-specific seroprevalence of a cross-section of the Dutch population for the vaccinations used in the Dutch National Immunisation Programme.
The hypothesis of the present study is to demonstrate that detection of a particular pattern (e.g., persistent vs. non-persistent) of myocardial (alpha)V(beta)3/5 expression by scintigraphy imaging at 3 and 8 weeks after MI can be used to determine…
It is our hypothesis that a combined life style intervention of exercise and weight loss will result in a reduction of pain and improvement of function of the affected hip joint, which will postpone a chirurgical intervention.
The EEG profile in responders to methylphenidate will be differ from the EEG profile in non-responders to methylphenidate (i.e. higher total power, increased theta/beta ratio and theta/alpha ratio).
There is an increase in concentrations of cytokines IL-1alpha, IL-1RA and IL-8 (as measured using Sebutapes) in the skin of the arm in healthy volunteers after mechanical loading of the skin, compared with an control measurement.
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Osteoporosis is common in patients with SCI and often causes fractures and is undertreated. Besides immobilization, other (endocrine) disturbances such as hypogonadism and/or growthhormone deficiency, which are seen after SCI with accompanying…
Application of sentinel node biopsy (in comparison to or combined with ultrasound guided fine needle aspiration cytology) improves the detection of occult lymph node metastases to a clinically relevant extent.
The combination of DLI with bortezomib given before and after the DLI improves the Graft versus Myeloma effect without effect on the Graft versus host disease
Exercise training is a feasible method to improve fitness (peak oxygen uptake), muscle strength and fatigue in children who survived cancer. Feasibility will be studied according to the number of performed training sessions and a structured…
The use of an objective device (accelerometer) to analyse function is more accurate than the currently used methods (observing by eyes).
Immediate, situational feedback is more effective than standard care alone, which, according to the Dutch IBS Guideline of General Practice (NHG, 2001), includes education, dietary advices and reassurance about the benign course of the disease.
Preterm born infants have more gastrointestinal symptoms such as constipation.
incomplete
Can predictors of reponse to anti-TNF therapy be identified by immunohistochemical analysis of synovial tissue obtained before initiation of treatment?
Heliuminduces early and late preconditioning after regional ischemia of the arm.
1. Vascular inflammation becomes activated several days to weeks before an acute coronary syndrome; 2. Biomarkers of (vascular) inflammation, endothelial activation and hypercoagulability become elevated before the event. Limited knowledge is…
1. Post operative pain treatment in orthopedic surgery in the Medical Center Alkmaar does not suffice; 2. Orthopedic patients undergoing total knee replacement use more morfine post OK than patients undergoing total hip replacement.
Insulin sensitivity is already reduced at birth in preterm SGA infants, compared to preterm AGA infants.
Mycophenolate is a selective inhibitor of inosine-monophosphate-dehydrogenase which leads to inhibition of the de novo pathway of nucleotide synthesis. The antiproliferative effect of mycophenolate mainly affects activated T- and B-lymphocytes…