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Recognition of critical illness at the Emergency Department

We expect that clinical judgement of medical personnel is better in predicting the development of critical illness compared to the Modified Early Warning Score

Performance of MRK, NexGen and LCS
Total Knee Prosthesis

Is there a significant difference in Anterior/Posterior stability between MRK, LCS and NexGen total knee prosthesis 1 year post-op?

Deep Brain Stimulation (DBS) in anorexia nervosa.

Anorexia Nervosa (AN) is a serious condition and forms a major public health problem. The disorder affects biological, psychological as well as social functioning, affects mainly young people, tends to take on a chronic course in a considerable…

Biomarkers in Infants at Risk of Developmental disorders - Part II

Atypical scores on the IMP-SINDA at infant age is predictive for developmental disorders at the age of 4 or 5 years.

Delirium treatment at the geriatric ward (DELTa G)
Treatment of delirium: rivastigmine or haloperidol as primary treatment for delirium in delirious patients on a geriatric ward.
A randomized placebo-controlled study.

Rivastigmine is as effective as haloperidol in the treatment of a delirium.

Delirium treatment at the surgical ward (DELTa S)
Treatment of delirium: rivastigmine or haloperidol as primary treatment for delirium in elderly patients with a fractured hip.
A randomized placebo-controlled study.

Rivastigmine is as effective in the treatment of delirium as Haloperidol.

The role of the intrinsic foot muscles in gait and balance in older adults

The size of intrinsic foot muscles is associated with gait biomechanics and balance in older adults

MLPA And Karyotyping, an Evaluation (M.A.K.E.).

The present study will establish the suggested equivalent preclinical diagnostic accuracy of MLPA in a clinical setting.

Tandem study: Theraplay in children with autism spectrum disorder and their parents.

Main question: Is Theraplay an effective treatment method for children with ASD and what is the effect of treatment with Theraplay on their parents? Prior RCTs proved that Theraplay leads, among other things, to a decrease in internalizing problem…

Handscan Registry Leeuwarden

The Handscan is supposed to be more accurate than the current widely used DAS 28, it might be able to measure subclinical disease activity. We want to investigate in which clinical situation, the handscan can be an aide in decision making or can be…

Taste function after chorda tympani injury

Sacrificing the chorda tympani causes less taste disfunction than stretching or damaging the chorda tympani nerve.

EyeLife

Individuals at the top 20% of genetic risk distribution for glaucoma are at a higher relative risk for having glaucoma.

The MEtformin-LIfestyle in Antipsychotic users trial

We expect that metformin in combination with lifestyle interventions reduces Antipsychotic induced Weight Gain compared to placebo in combination with lifestyle interventions.

A Randomized, Double-blind, Placebo-controlled Trial on the Prevention of Chronic Postoperative Pain after Inguinal Hernia and Knee Surgery by Postoperative Treatment with Tapentadol

We hypothesize that treatment with Tapentadol will reduce the development of chronic postoperative pain by enhancing or maintaining CPM responses and possibly reducing central sensitization. We hypothesize that a 4-week treatment with Tapentadol…

GBA-PD Patient Imaging study of LTI-291 versus placebo.

The HipPOCUS-trial

The sensitivity of POCUS, performed by emergency physicians is ≥ 90%

Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-61393215 in Healthy Participants

PK and PD effects of JNJ-61393215