29 resultaten
Targeted Next Generation Sequencing (NGS) can distinguish benign pancreatic diseases, such as pancreatitis, from pancreatic malignancies during the diagnostic proces of patients with an uncertain diagnosis and treatment plan.
Multiple sclerosis (MS) is a brain disease, in which myelin sheaths in the brain and spinal cord are damaged. If repair of myelin damage is incomplete, nerve terminals will be irreversibly destroyed, leading to neurological symptoms. Ineffective…
Enhanced endoscopic imaging, including high-definition white light endoscopy and virtual chromoendoscopy, alongside targeted biopsies provides an accurate and reproducible assessment of chronic atrophic gastritis disease extent and staging, when…
We hypothesize that the commercially available CE-marked over the scope Pro-select Padlock clip is able to clip a gastic/duodenal SET, where after full thickness resection of the SET can be achieved using a normal
The aim of this research project is to investigate cannabidiol as a new medicine to target the cannabinoid system in the reduction of anxiety disorder symptoms. The research question is whether cannabidiol, as an augmentation strategy of exposure…
The primary objective is to determine the efficacy of angina control with this type of Peripheral Subcutaneous Field Stimulation (PSFS) at three months and 12 months. This will be assessed in a patient diary by the number of angina attacks and the…
We expect brain activity and brain reactivity to change as satiation progresses. ROI are : Brainstem (dorsal vagal complex (DVC), nucleus tractus solitarius (NTS), parabrachial nucleus (PBN)), Hypothalamus, Insula, overlying operculum, secondary:…
Alemtuzumab induction therapy in ABOi kidney transplantation lowers the incidence of cellular-mediated BPAR compared to rituximab induction, without affecting the number of antibody-mediated rejections.
The effectiveness of a health game based on an Evaluative Conditioning paradigm compared to a control game will be tested in a Dutch sample of adolescents. It is expected that the adolescents in the intervention condition will show a increased…
The objective is to investigate the effect of cannabidiol (synthetic) as compared to placebo in facilitating fear extinction and reducing fear retention and reinstatement.
Certain patient-specific factors contribute significantly to the outcome of delivery after a cesarean section in a Dutch hospital setting. These factors influence the decision to initiate trial of labour (TOL) or plan for an elective repeat…
Project goal: To increase the percentage of HIV-infected immigrant patients with an HIV-RNA <20 copies/ml (successful treatment) and to reduce the transmission of HIV within this ‘key population’(non-European immigrants). Additionally,…
The use of ECLS can lead to systemic inflammatory response. It is likely that ECLS affects red blood cell and platelet function after its initiation, the time course of these changes and their clinical relevance is yet unclear.
Can imaging surveillance frequency be safely reduced in a select group of EVAR patients, i.e. patients with an asymptomatic infrarenal abdominal aortic aneurysm (AAA) that underwent EVAR without abnormalities on the initial postoperative CTA.
Neuropsychiatric symptoms (e.g. apathy, depression, anxiety, agitation) are very common in patients with Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD) and are negatively related to various clinical outcomes. However, despite growing…
Recently, (changes in) the gut microbiome (flora / bacteria) have been associated with obesity and insulin resistance, and other cardiovascular risk factors or atherogenic processes. Venous thrombosis shares these risk factors, probably by a shared…
We hypothesize that anxiety symptoms worsen after follow-up imaging compared to patients baseline anxiety levels.
Addition of alternative tests (TEG/ROTEM® and/or TGA) which reflect the whole hemostatic status of a patient might help recognizing the level of thrombin formation and fibrinolysis and improve care in ECMO patients and potentially reduce the risk of…
In this RCT we investigate the effects of two school-based physical activity interventions (aerobic exercises versus coordinative exercises) in primary school children on executive functions and academic achievement. We hypothesize that both aerobic…