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Hypersalivation or sialorrhea is one of the most frequently occuring side effects of clozapine use with an incidence ranging from 30 to 90%. In most cases it occurs at the start of clozapine treatment, mostly at night and persists during further…
Deep brain stimulation of the nucleus accumbens decreases drug use and craving in treatment refractory heroin and/or cocaine dependence.
The goal of the study is to: 1. Improve daily functioning in patients with schizophrenia; 2. To improve behavioral observation in psychiatric nurses; 3. To implement CAT in the usual treatment of patients with severe mental illness.
We hypothesize that implementation of a workers's health surveillance and consecutive interventions will lead to prevention of injury and disability, health improvement, and eventually sustained employment.
We hypothesize that in this short term study the testproducts with added fibre will increase satiety, slower gastric emptying, will give a later blood glucose peak and that it will decrease energy intake when compared to the controlproduct.
Objective of this study is to assess the sensitivity of performance in a number of widely used tests for measuring driver impairment to the dose-effects of alcohol.
Development and validation of a clinical Proof-of-Concept study paradigm for determing the clinical utility of respiratory stimulants over the potential therapeutic dose range in the face of opioid respiratory depression and presences of hypercapnia…
The aim is to investigate the effects, costs, and feasibility of an evidence-based professional-directed implementation strategy to implement the Dutch peri-operative guidelines, i.e. to achieve a higher adherence to these guidelines. It is…
Tamoxifen pharmacokinetics may be influenced by circadian rhythm. Endoxifen exposure may differ between morning administration of tamoxifen and administration in the evening. Amendment (1-apr-2013): Tamoxifen pharmacokinetics may be influenced by…
A follow-up clinic for intensive care units (ICU) survivors reduces the incidence of post traumatic stress disorder (PTSD) after 1 year of follow-up.
Tinnitus (Aurium) is a symptom characterized by the perception of sound or noise in the absence of any objective external physical source. This disorder affects millions of people worldwide; its precise pathophysiologic mechanism is unknown. It has…
1. Evaluation of pulmonary deposition of inhaled Tobramycin with 99mTc-DTPA tracer is feasible using SPECT-CT scans; 2a. Pulmonary deposition of Tobramycin improves with concomitant inhalation of carbon dioxide enriched ambient air; 2b. Pulmonary…
Hyperglycaemia alters the sustained hypoxic pulmonary vasoconstriction (HPV) and the hypoxic ventilatory response (HVR).
The objective is to identify a formulation of ModraCape001 that will release capecitabine in vivo over a time-period of about 18 hours. We hypothesize that prolonged exposure, without a high peak exposure to capecitabine, improves the benefit/risk…
We hypothesise that fasting-induced insulin resistance will result in decreased glucose uptake and activity of brown adipose tissue (BAT). In addition, prolonged fasting will lead to reduced mitochondrial uncoupling in skeletal muscle, which is…
To investigate if flavour flavour learning is an effective mechanism to increase children's vegetable intake.
A high-glucose load can lead to inflammation and it is thought that recurring hyperglycemia may lead to insulin resistance. Our aim is to prevent glucose-induced inflammation and decreased insulin sensitivity with broccoli seedlings which are…
The intention to change behavior is related to changes in multiple physiological variables. Thermal comfort and thermal sensation are related to these physiological parameters. Furthermore, the intention of behavior is related to changes in thermal…
We expect that OT administration in PTSD patients and controls will dampen amygdala activity and increase reward sensitivity. We hypothesize to see a group by treatment interaction effect, such that the magnitude of the neural effects of OT…