48 resultaten
The present mode of (tonic) SCS is accompanied by paraesthesia in the area of stimulation. Recently, a new mode of SCS has been developed which makes it possible to apply spinal cord stimulation without paraesthesias. This mode is called burst…
It is hypothesized that the behavioral effect (i.e. slower RT and impaired attention) of a non-sedative antihistamine will be apparent in combination with a Pgp-blocker, but will not be apparent when administered alone. This, because when a non-…
The behavioural effects of an antihistamine is apparent in the evening after an evening dose, but will be smaller in the morning after a morning dose condition due to the excessive release of histamine shortly after awaking.
1. At baseline, memory performance and neuroendocrine reactions are expected to differ between novice MDMA (< 10 ecstasy exposures) users and heavy/experienced MDMA users (>100 ecstasy exposures). It is hypothesized that heavy MDMA…
We hypothesize that dietary nitrate supplementation improves muscle strength and muscle endurance performance.
Our hypothesis is that growth hormone threatment in adults with Prader-Willi Syndrome will improve their metabolic and cardiovascuar health, thereby resulting in a reduced mortality.
The post-prandial rise in total amino acid, proline and glycine concentration following a single bout of resistance exercise will be the highest in the 20 gr whey combined with 10 gr collagen compared to all other test drinks
Overall, diagnostic accuracy will be lower on subjected-to-bias than on not-subjected-to-bias cases, but the difference in accuracy will be smaller in the group of physicians with higher knowledge of critical diagnostic features. Overall, the…
Acute challenges with cocaine and cannabis will induce two opposing dopaminergic states in the brain. Cocaine will stimulate dopamine release leading to hyperdopaminergia whereas cannabis will reduce central dopamine levels resulting in…
If COMET increases the saliency of positive autobiographical memories, then memories that are activated during COMET (relative to no intervention control) should show an increase over time on all primary outcome measures, irrespective of medication…
It is expected that dopaminergic antagonism by haloperidol 2mg or 3mg wil result in specific inhibition of both bias and disengagement related activity as measured by EEG in combination with computertasks. Specifically, we expect that, dopamine…
Fluoxetine and movement observation are able to increase cortical activity after stroke
Dronabinol impairs driving performance in light cannabis users, but not in heavy users, because of tolerance to the impairing effects.
Metformin and hydrochlorothiazide attenuate polyuria in patients treated with tolvaptan
As the pain quality item “unpleasantness” delineates EB pain, we hypothesize the modulation of affective pain processing in the brain by way of intervention with Transvamix (a CBM comprising THC and CBD) - objectified by functional magnetic…
This study tests the hypothesis that reward mechanisms in PD are dysfunctional and that this dysfunction is correlated with an increased severity of symptoms of apathy, depression and HDD.
Modulation of phosphate intake can affect the antiproteinuric efficacy of RAAS-blockade therapy in CKD patients
The present study will investigate: 1. Whether drug-related cues activate the same neural networks as does the administration of the drug itself; 2. The implicit and explicit associations of alcohol and cannabis users; 3. The effect of acute doses…
A single oral doses of amino acids may play a role as insulin secretagogues.