331 resultaten
Different studies have shown that a hunter-gatherer type diet is effective in improving glucose regulation and lipid profile. I want to investigate if the hypothese that this type of diet also reduces the number of physical and psychological…
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Acid-reducing drugs, such as PPIs, may profoundly decrease solubility and, as a result, (negatively) affect the bioavailability of afatinib. Since a PPI is often used concomitantly during afatinib therapy, this DDI confronts physicians, patients,…
To evaluate the anti-inflammatory effects of 3 months statin therapy on vessel wall inflammation by means of FDG PET/CT in patients with CKD.
The optimal management of locoregionally advanced NSCLC is evolving. Multimodality treatment is rapidly becoming the most common approach to stage III NSCLC. ASCO guidelines recommend initial chemotherapy (platinum-based, 2 or 3 cycles) combined…
The aim was to study the effect of apple cider vinegar on the rate of gastric emptying on insulin-dependent diabetes mellitus patients with diabetic gastroparesis.
Targeted Next Generation Sequencing (NGS) can distinguish benign pancreatic diseases, such as pancreatitis, from pancreatic malignancies during the diagnostic proces of patients with an uncertain diagnosis and treatment plan.
Is it possible / desirable to move Orencia treatment from the hospital to the home situation?
Comparison of two new techniques for detection of small bowel pathology: MR enteroclysis and videocapsule enteroscopy with double-balloon enteroscopy with respect to diagnostic yield, accuracy of findings, and patient preference.
For patients with breast cancer who are not applicable for breast-saving treatment (because of tumor characteristics), who prefer an amputation or who undergo a prophylactic amputation an immediate breast reconstruction is a standard offer. A…
Phenylalanine supplementation can result in higher phenylalanine concentrations without causes tyrosine concentrations to rise too much
The carotid artery reactivity-test will have independent prognostic value compared to the current, standard prognostic tests (i.e. ankle-brachial-index, walking distance) for patients with peripheral artery disease
Obesity is a growing world wide problem. In The Netherlands, about 10% of all men and women have a BMI of 30 kg/m2 or more. Obesity is a chronic, uncurable metabolic disorder, which is characterised by excessive fatstorage at unfavorable places.…
By using a surgical safety checklist, the incidence of postoperative complications will decrease.
The hypothesis is that low dose GC therapy exerts its anti-inflammatory effect by virtue of a first-pass effect through the liver. It is difficult to directly address the hypothesis, but there is an indirect way of doing so: if indeed low dose GCs…
Deep brain stimulation of the nucleus accumbens decreases drug use and craving in treatment refractory heroin and/or cocaine dependence.
Multiple sclerosis (MS) is a brain disease, in which myelin sheaths in the brain and spinal cord are damaged. If repair of myelin damage is incomplete, nerve terminals will be irreversibly destroyed, leading to neurological symptoms. Ineffective…
The aim of this phase I study is to assess the extent of intestinal absorption of rivaroxaban and dabigatran etexilate in adult patients with short bowel syndrome requiring long-term TPN.
The primary objective of this study is to statistically determine the optimal contact-pressure (compression force divided by breast-paddle contact area) for breast compression in Digital Breast Tomosynthesis. In this study, ¡°optimal¡± is defined as…