891 resultaten
Patient with incurable disseminated left-sided colonic cancer are better palliated by colonic stenting than surgery measured by hospital free survival in "good health"(WHO-score 0 or 1) Colonic stenting is cost effective in patients with…
Previous trials showed that both doxorubicin and thalidomide have anti-tumor activity against hepatocellular carcinoma (HCC). There are indications that these two agents interact synergistically and have non-overlapping toxicity profiles. This trial…
Stroke patients frequently complain of excessive fatigue, both in post-acute and in the chronic stage of their illness. The prevalence of severe fatigue is estimated between 28-73%, even in patients who seem to recover well. This may lead to…
We hypothize that in low risk women amniotomy at home for post term pregnancy will result in more sponteneous birth (defined as labour and birth without any obstetric intervention but amniotomy)resulting in lower costs during birth.
After training one arm with a prosthetic simulator it is expected that the other arm will improve.
The OptiScanner provides accurate blood glucose levels in critically ill patients.
Chronic Obstructive Pulmonary Disease (COPD) is a chronic, progressive lung disease. The prevalence and associated costs of COPD are projected to increase the upcoming decades. The treatment of COPD aims to reduce risk factors, prevent disease…
Subjects in the PCD-04 arm will show less anthracyclin-induced cardiotoxicty then subjects in the placebo arm.
We tested the hypothesis of the superior effectiveness of an online preventive self help intervention for problem drinkers based on cognitive-behavioural self control principles vis-à-vis an online psycho-education brochure for problem drinkers.
Employees in the health care service are at high risk to develop common mental health complaints. These can negatively affect work functioning, with possible serious consequences for the quality of care. It is crucial to keep health care workers…
The addition of metronomic cyclophosphamide to standard 2nd line treatment with everolimus will improve progression free survival of patients at 4 months from the reported value of 50% to 70% in patients with mRCC.
In RA patients that achieved disease remission by treatment with the combination of a csDMARD and anti-TNF, there is a difference in (cost-)effectiveness when medication is tapered according to strategy A (csDMARD first) compared to strategy B (anti…
To provide evidence that restoration of euthyroidism (normal TSH) improves thyrotoxic symptoms and signs and quality of life and lowers the risk of subsequent atrial fibrillation and bone loss in subjects with endogenous subclinical hyperthyroidism.
Inhibition of CYP2D6 enzymes by SSRIs may lead to reduced endoxifen plasma concentrations and thereby possibly influence tamoxifen treatment outcome. Paroxetine is a potent CYP2D6 inhibitor and strongly reduces endoxifen plasma concentrations.…
We test the hypothesis that guided self-help is not less effective and not more expensive than care-as-usual.
Primary outcomes with respect to living donation are: Knowledge, risk perception, subjective norm, communication and intention to engage in a certain behavior (choosing living donation). These concepts will be measured among the patient as well as…
Intranasal administration of cobalamin can be used as an alternative for the standard intramuscular injection of cobalamin in cobalamin deficient patients.
Nebulised DNase has a decreasing effect on the duration of a hospital admission in infants admitted with an RSV-bronchiolitis.
To evaluate the impact of three different implementation strategies for implementing IBSM in current clinical practice, we have proposed the following three hypotheses: 1. Hypothesis 1 (Reach): More general practices will participate in IBSM in the…