The use of an-image based CAD system is feasible and enables endoscopic detection of Barrett neoplasia
ID
Bron
Verkorte titel
Aandoening
Barrett Esophagus, Barrett neoplasia
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
To evaluate feasibility of the workflow of using a re al-time, image-based CAD system in the endoscopy suite.
Achtergrond van het onderzoek
Barrett’s Esophagus (BE) is a known precursor for esophageal adenocarcinoma (EAC). BE patients undergo regular endoscopic
surveillance by general endoscopists to detect EAC at an early stage. However, endoscopic detection of early neoplasia is difficult
and early lesions are therefore often missed. Primarily, this is due to its subtle appearance.
The ability of modern-day computers to automatically recognize informative patterns in data sets can potentially improve endoscopic
detection of early neoplastic BE. Recently, a CAD system has been developed by our group that can automatically detect and
localize early neoplastic Barrett lesions on endoscopic WLE images with high accuracy.
The aim of this pilot study is to interrogate the feasibility of the endoscopic workflow, using this image-based CAD system real-time in the
endoscopy suite.
Doel van het onderzoek
The use of an-image based CAD system is feasible and enables endoscopic detection of Barrett neoplasia
Onderzoeksopzet
Outcome measures apply to the endoscopic procedure. No further time point apply to this study.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Age>18 years;
- Patients with NDBE referred for endoscopic surveillance, or patients referred for endoscopic work-up of HGD or
EAC likely to require endoscopic resection (EMR or ESD);
- Signed informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Prior history of surgical or endoscopic treatment for oesophageal neoplasia;
- Presence of erosive esophagitis (Los Angeles classification ≥A);
- Inability to undergo EMR/ESD and/or obtain biopsies (e.g. due to anticoagulation, coagulation disorders,
varices).
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7544 |
| Ander register | MEC Amsterdam University Medical Centers, Location AMC : METC 2018_334 |