A model based on the combination of clinical prognostic factors and features extracted from tumor contours from CT-PET and biological characteristics obtained from tissue or blood has a high accuracy to predict overall survival and local control…
ID
Bron
Aandoening
Larynx cancer
Radiotherapy
Prediction
PET scan
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Overall survival.
Achtergrond van het onderzoek
Accurate prediction of survival and local control can help in the selection of patients for optimized treatment. Therefore it is valuable to develop an accurate, data-driven model to predict overall survival and local control in larynx cancer patients in order to individualize treatment. CTPET-imaging might have a predictive value for response in larynx cancer. In this study CTPET imaging is combined with clinical prognostic factors and blood and tissue characteristics to develop models and corresponding nomograms to predict response sufficiently accurate to use in trials and in the clinic.
Doel van het onderzoek
A model based on the combination of clinical prognostic factors and features extracted from tumor contours from CT-PET and biological characteristics obtained from tissue or blood has a high accuracy to predict overall survival and local control after radiotherapy in larynx cancer.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
1. FDG-PET imaging (pretreatment);
2. Blood sampling (facultative);
3. Tissue sampling (facultative);
4. FDG-PET imaging (posttreatment, facultative).
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Histological proven larynx cancer;
2. Only primary tumors; no recurrences;
3. Only radiotherapy treatment;
4. 18 years or older.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Other pathology then squamous cell.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2139 |
| NTR-old | NTR2263 |
| Ander register | Trialnummer Maastro Clinic : 08-31-10/12 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |