We expect that SAI has strong correlations with tracer binding of [18F]FEOBV, especially in the patients with advanced PD.
Bron
Verkorte titel
Aandoening
Parkinson's disease
Ondersteuning
Onderzoeksproduct en/of interventie
Geen registraties gevonden.
Uitkomstmaten
Primaire uitkomstmaten
The main study parameter is the relationship between baseline SAI and [18F]FEOBV PET imaging.
Achtergrond van het onderzoek
Rationale: Parkinson’s disease (PD) is a complex neurodegenerative disorder, involving multiple neurotransmitter systems. It has been shown that degeneration of the cholinergic system in PD is related both motor and nonmotor symptoms, including cognitive impairment, REM-sleep behavioural disorder (RBD), visual hallucinations (VHs) and hyposmia, postural instability and gait disorder. Several methods exist for imaging of the cholinergic system in vivo, although they are not routinely performed in clinical practice due to their cost, limited availability and radiation burden for the patient. Short-latency afferent inhibition (SAI) might be a relatively cheap and non-invasive alternative for fast in vivo assessment of the cholinergic system.
Objective: Our primary objective is to validate SAI as a measure for cholinergic innervation using [18F]FEOBV PET imaging as a reference.
Doel van het onderzoek
We expect that SAI has strong correlations with tracer binding of [18F]FEOBV, especially in the patients with advanced PD.
Onderzoeksopzet
1
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Willingness to cooperate and sign written informed consent
Patients:
- Clinical diagnosis of idiopathic Parkinson’s disease by a neurologist with disease duration between 5 and 15 years.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Incapable to provide informed consent (e.g. in case of severe dementia)
- Treatment with drugs with anticholinergic activity, as listed in Chew et al. 2008 and Ehrt et al. 2010
- Current or recent treatment with ChEIs
- Presence of deep brain stimulation implants
- (Suspected) pregnancy
- Migraine
- Epilepsy
- Participation in a scientific research study during the past year involving radiation
- MRI contra-indications, e.g.
o Ferrous objects in or around the body (e.g. braces, pacemaker, metal fragments)
o Claustrophobia
- Insufficient knowledge of the Dutch language
Control subjects:
- History of neurological or neurodegenerative disorder
Patients:
- Moderate to severe cognitive impairment, but no dementia, according to diagnostic criteria
PD-D:
- Unsafe or irresponsible to postpone treatment with ChEIs, according to treatment provider
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
Register | ID |
---|---|
NTR-new | NL7838 |
Ander register | UMCG : 201900751 |