This is an exploratory brain imaging study, measuring brain oxygenation over 10 regions of interest. Based on the 'cross-talk' hypothesis form Lewis and Barker (2009), we hypothesize that FOG might be associated with increased activity in…
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Verkorte titel
Aandoening
Parkinson's disease; Freezing of Gait
Ondersteuning
Onderzoeksproduct en/of interventie
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Uitkomstmaten
Primaire uitkomstmaten
change in fNIRS activity (i.e. oxygenated hemoglobin and deoxygenated hemoglobin) relative to baseline in 10 regions of interest: the sensorimotor cortex, the supplementary motor area, the premotor cortex, the dorsolateral prefrontal cortex and the posterior parietal cortex (in both hemispheres).
Achtergrond van het onderzoek
Freezing of gait (FOG) is one of the most debilitating symptoms in Parkinson’s disease (PD). Neuroimaging studies have tried to unravel it’s underlying neural mechanism, but are hampered by severe limitations in study design because subjects need to lay supine and still in scanners. This study proposes to study FOG in real-time by using multichannel functional near-infrared spectroscopy (fNIRS), a mobile neuroimaging technique that has been successfully applied in other gait studies.
Doel van het onderzoek
This is an exploratory brain imaging study, measuring brain oxygenation over 10 regions of interest. Based on the 'cross-talk' hypothesis form Lewis and Barker (2009), we hypothesize that FOG might be associated with increased activity in cognitive cortices (i.e. prefrontal cortex, posterior parietal cortex) and decreased activity in the motor cortices (i.e. sensorimotor cortex, supplementary motor area, premotor cortex) when compared to normal walking.
Onderzoeksopzet
Experiment is conducted during a single visit to the laboratory of Nijmegen
Onderzoeksproduct en/of interventie
25 persons with Parkinson's disease OFF anti-Parkinson medication and 25 controls will perform a walking task while brain activity is measured with fNIRS. The walking task includes passages through narrow doorways and 180 degree turns in order to trigger FOG.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- > 18 years old
- idiopathic Parkinson's disease
- experiencing freezing of gait more than once a day
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- comorbidities that cause severe gait impairments
- comorbidities that interfere with fNIRS recording (i.e. previous brain surgery, structural cerebral lesions)
- inabilty to comply with the protocol (inability to walk 150 m or make a half turn unaided, inability to walk 10 seconds without experiencing freezing of gait, severe cognitive impairments)
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Toelichting
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
Register | ID |
---|---|
NTR-new | NL8021 |
CCMO | NL70915.091.19 |